ID E9PFU5_HUMAN Unreviewed; 524 AA. AC E9PFU5; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 16-JAN-2019, entry version 58. DE SubName: Full=Pituitary adenylate cyclase-activating polypeptide type I receptor {ECO:0000313|Ensembl:ENSP00000386395}; GN Name=ADCYAP1R1 {ECO:0000313|Ensembl:ENSP00000386395}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386395, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000386395, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000386395} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC {ECO:0000256|SAAS:SAAS00547938}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC006466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510285; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF511015; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF511016; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PFU5; -. DR MaxQB; E9PFU5; -. DR PRIDE; E9PFU5; -. DR Ensembl; ENST00000409489; ENSP00000386395; ENSG00000078549. DR UCSC; uc003tcf.2; human. DR EuPathDB; HostDB:ENSG00000078549.14; -. DR HGNC; HGNC:242; ADCYAP1R1. DR OpenTargets; ENSG00000078549; -. DR GeneTree; ENSGT00940000157362; -. DR OMA; CKAIMVF; -. DR PhylomeDB; E9PFU5; -. DR ChiTaRS; ADCYAP1R1; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000078549; Expressed in 121 organ(s), highest expression level in nucleus accumbens. DR ExpressionAtlas; E9PFU5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR GO; GO:0004999; F:vasoactive intestinal polypeptide receptor activity; IEA:InterPro. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR Gene3D; 4.10.1240.10; -; 1. DR InterPro; IPR017981; GPCR_2-like. DR InterPro; IPR036445; GPCR_2_extracell_dom_sf. DR InterPro; IPR001879; GPCR_2_extracellular_dom. DR InterPro; IPR002285; GPCR_2_PACAP_1_rcpt. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR017983; GPCR_2_secretin-like_CS. DR PANTHER; PTHR12011:SF228; PTHR12011:SF228; 1. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF02793; HRM; 1. DR PRINTS; PR00249; GPCRSECRETIN. DR PRINTS; PR01156; PACAPRECEPTR. DR SMART; SM00008; HormR; 1. DR SUPFAM; SSF111418; SSF111418; 1. DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1. DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1. DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998}; KW Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:E9PFU5}; KW Receptor {ECO:0000256|SAAS:SAAS00978998}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transducer {ECO:0000256|SAAS:SAAS00978998}; KW Transmembrane {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 524 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003242835. FT TRANSMEM 155 175 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 187 205 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 241 260 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 267 287 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 307 332 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 407 427 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 439 459 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 33 138 G_PROTEIN_RECEP_F2_3. FT {ECO:0000259|PROSITE:PS50227}. FT DOMAIN 153 460 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. SQ SEQUENCE 524 AA; 59619 MW; 1607BB5B7BE93829 CRC64; MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLT NLSPRVPKKA REDPLPVPSD QHSLPFLSCV QKCYCKPQRA QQHSCKMSEL STITLRLARS TLLLIPLFGI HYTVFAFSPE NVSKRERLVF ELGLGSFQGF VVAVLYCFLN GEVQAEIKRK WRSWKVNRYF AVDFKHRHPS LASSGVNGGT QLSILSKSSS QIRMSGLPAD NLAT //