ID   E9PF78_HUMAN            Unreviewed;       196 AA.
AC   E9PF78;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 44.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 22 {ECO:0000313|Ensembl:ENSP00000413899};
DE   Flags: Fragment;
GN   Name=ADAM22 {ECO:0000313|Ensembl:ENSP00000413899};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413899, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000413899, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000413899}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC004992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PF78; -.
DR   PeptideAtlas; E9PF78; -.
DR   PRIDE; E9PF78; -.
DR   Ensembl; ENST00000412441; ENSP00000413899; ENSG00000008277.
DR   UCSC; uc064fce.1; human.
DR   EuPathDB; HostDB:ENSG00000008277.14; -.
DR   HGNC; HGNC:201; ADAM22.
DR   OpenTargets; ENSG00000008277; -.
DR   GeneTree; ENSGT00940000156889; -.
DR   ChiTaRS; ADAM22; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000008277; Expressed in 169 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; E9PF78; baseline and differential.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PF78};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    196       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245156.
FT   DOMAIN       97    192       Pep_M12B_propep.
FT                                {ECO:0000259|Pfam:PF01562}.
FT   NON_TER     196    196       {ECO:0000313|Ensembl:ENSP00000413899}.
SQ   SEQUENCE   196 AA;  21893 MW;  8498C760EC266DE9 CRC64;
     MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG
     GEDESRHDAL DTRVRGDLGG PQIQMFLKSE SQKTIYQIQL THVDQASFQV DAFGTSFILD
     VVLNHDLLSS EYIERHIEHG GKTVEVKGGE HCYYQGHIRG NPDSFVALST CHGLHGMFYD
     GNHTYLIEPE ENDTTQ
//