ID E9PEK4_HUMAN Unreviewed; 671 AA. AC E9PEK4; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 16-JAN-2019, entry version 63. DE SubName: Full=Macrophage colony-stimulating factor 1 receptor {ECO:0000313|Ensembl:ENSP00000422212}; GN Name=CSF1R {ECO:0000313|Ensembl:ENSP00000422212}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422212, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000422212, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000422212} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC011382; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PEK4; -. DR jPOST; E9PEK4; -. DR MaxQB; E9PEK4; -. DR PeptideAtlas; E9PEK4; -. DR PRIDE; E9PEK4; -. DR Ensembl; ENST00000504875; ENSP00000422212; ENSG00000182578. DR UCSC; uc063ipr.1; human. DR EuPathDB; HostDB:ENSG00000182578.13; -. DR HGNC; HGNC:2433; CSF1R. DR OpenTargets; ENSG00000182578; -. DR eggNOG; KOG0200; Eukaryota. DR eggNOG; COG0515; LUCA. DR GeneTree; ENSGT00940000155506; -. DR ChiTaRS; CSF1R; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000182578; Expressed in 202 organ(s), highest expression level in spleen. DR ExpressionAtlas; E9PEK4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0019955; F:cytokine binding; IEA:InterPro. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:InterPro. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 5. DR InterPro; IPR030658; CSF-1_receptor. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR001824; Tyr_kinase_rcpt_3_CS. DR Pfam; PF00047; ig; 1. DR Pfam; PF07714; Pkinase_Tyr; 1. DR PIRSF; PIRSF500947; CSF-1_receptor; 1. DR SMART; SM00409; IG; 5. DR SMART; SM00408; IGc2; 2. DR SUPFAM; SSF48726; SSF48726; 5. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|PIRSR:PIRSR500947-51}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR500947-52}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR500947-51}; KW Proteomics identification {ECO:0000213|MaxQB:E9PEK4, KW ECO:0000213|PeptideAtlas:E9PEK4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 671 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003244041. FT TRANSMEM 514 538 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 21 85 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 203 290 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 402 502 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 582 671 Protein kinase. FT {ECO:0000259|PROSITE:PS50011}. FT NP_BIND 588 596 ATP. {ECO:0000256|PIRSR:PIRSR500947-51}. FT BINDING 616 616 ATP. {ECO:0000256|PIRSR:PIRSR500947-51}. FT DISULFID 42 84 {ECO:0000256|PIRSR:PIRSR500947-52}. FT DISULFID 127 177 {ECO:0000256|PIRSR:PIRSR500947-52}. FT DISULFID 224 278 {ECO:0000256|PIRSR:PIRSR500947-52}. FT DISULFID 419 485 {ECO:0000256|PIRSR:PIRSR500947-52}. SQ SEQUENCE 671 AA; 74269 MW; 205F93FFECC8D891 CRC64; MGPGVLLLLL VATAWHGQGI PVIEPSVPEL VVKPGATVTL RCVGNGSVEW DGPPSPHWTL YSDGSSSILS TNNATFQNTG TYRCTEPGDP LGGSAAIHLY VKDPARPWNV LAQEVVVFED QDALLPCLLT DPVLEAGVSL VRVRGRPLMR HTNYSFSPWH GFTIHRAKFI QSQDYQCSAL MGGRKVMSIS IRLKVQKVIP GPPALTLVPA ELVRIRGEAA QIVCSASSVD VNFDVFLQHN NTKLAIPQQS DFHNNRYQKV LTLNLDQVDF QHAGNYSCVA SNVQGKHSTS MFFRVVESAY LNLSSEQNLI QEVTVGEGLN LKVMVEAYPG LQGFNWTYLG PFSDHQPEPK LANATTKDTY RHTFTLSLPR LKPSEAGRYS FLARNPGGWR ALTFELTLRY PPEVSVIWTF INGSGTLLCA ASGYPQPNVT WLQCSGHTDR CDEAQVLQVW DDPYPEVLSQ EPFHKVTVQS LLTVETLEHN QTYECRAHNS VGSGSWAFIP ISAGAHTHPP DEFLFTPVVV ACMSIMALLL LLLLLLLYKY KQKPKYQVRW KIIESYEGNS YTFIDPTQLP YNEKWEFPRN NLQFGKTLGA GAFGKVVEAT AFGLGKEDAV LKVAVKMLKS TAHADEKEAL MSELKIMSHL GQHENIVNLL GACTHGGTVA SPARVWTPMW R //