ID   E9PED7_HUMAN            Unreviewed;       354 AA.
AC   E9PED7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 74.
DE   SubName: Full=Stromelysin-3 {ECO:0000313|Ensembl:ENSP00000408070};
GN   Name=MMP11 {ECO:0000313|Ensembl:ENSP00000408070};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408070, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408070, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [2] {ECO:0000313|Ensembl:ENSP00000408070}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000486551}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS01067066};
CC   -!- SIMILARITY: Belongs to the peptidase M10A family.
CC       {ECO:0000256|SAAS:SAAS00542437}.
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DR   EMBL; AP000349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E9PED7; -.
DR   PeptideAtlas; E9PED7; -.
DR   PRIDE; E9PED7; -.
DR   Ensembl; ENST00000437086; ENSP00000408070; ENSG00000099953.
DR   Ensembl; ENST00000629514; ENSP00000486551; ENSG00000275365.
DR   UCSC; uc002zxy.4; human.
DR   EuPathDB; HostDB:ENSG00000099953.9; -.
DR   HGNC; HGNC:7157; MMP11.
DR   OpenTargets; ENSG00000099953; -.
DR   eggNOG; KOG1565; Eukaryota.
DR   eggNOG; ENOG410XQ5D; LUCA.
DR   GeneTree; ENSGT00940000156340; -.
DR   ChiTaRS; MMP11; human.
DR   Proteomes; UP000005640; Chromosome 22.
DR   Bgee; ENSG00000099953; Expressed in 124 organ(s), highest expression level in chorionic villus.
DR   ExpressionAtlas; E9PED7; baseline and differential.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
DR   CDD; cd04278; ZnMc_MMP; 1.
DR   Gene3D; 2.110.10.10; -; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR036375; Hemopexin-like_dom_sf.
DR   InterPro; IPR018487; Hemopexin-like_repeat.
DR   InterPro; IPR018486; Hemopexin_CS.
DR   InterPro; IPR033739; M10A_MMP.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001818; Pept_M10_metallopeptidase.
DR   InterPro; IPR021190; Pept_M10A.
DR   InterPro; IPR021158; Pept_M10A_Zn_BS.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR028705; Stromelysin-3.
DR   PANTHER; PTHR10201:SF20; PTHR10201:SF20; 1.
DR   Pfam; PF00045; Hemopexin; 1.
DR   Pfam; PF00413; Peptidase_M10; 1.
DR   PIRSF; PIRSF001191; Peptidase_M10A_matrix; 1.
DR   PRINTS; PR00138; MATRIXIN.
DR   SMART; SM00120; HX; 1.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF50923; SSF50923; 1.
DR   PROSITE; PS00546; CYSTEINE_SWITCH; 1.
DR   PROSITE; PS00024; HEMOPEXIN; 1.
DR   PROSITE; PS51642; HEMOPEXIN_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00473618};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00973795};
KW   Metalloprotease {ECO:0000256|SAAS:SAAS00473618};
KW   Protease {ECO:0000256|SAAS:SAAS00473618};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PED7,
KW   ECO:0000213|PeptideAtlas:E9PED7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|SAAS:SAAS00973802}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    354       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013982244.
FT   DOMAIN       87    243       ZnMc. {ECO:0000259|SMART:SM00235}.
FT   REPEAT      275    323       Hemopexin. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01011}.
FT   REPEAT      324    354       Hemopexin. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01011}.
FT   ACT_SITE    200    200       {ECO:0000256|PIRSR:PIRSR001191-1}.
SQ   SEQUENCE   354 AA;  38783 MW;  81CF948810975CA8 CRC64;
     MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDAHH LHAERRGPQP WHAALPSSPA
     PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRILR FPWQLVQEQV RQTMAEALKV
     WSDVTPLTFT EVHEGRADIM IDFARYWHGD DLPFDGPGGI LAHAFFPKTH REGDVHFDYD
     ETWTIGDDQG TDLLQVAAHE FGHVLGLQHT TAAKALMSAF YTFRYPLSLS PDDCRGVQHL
     YGQPWPTVTS RTPALGPQAG IDTNEIAPLE PDAPPDACEA SFDAVSTIRG ELFFFKAGFV
     WRLRGGQLQP GYPALASRHW QGLPSPVDAA FEDAQGHIWF FQGTTGVSTP APGV
//