ID   E9PEC3_HUMAN            Unreviewed;       423 AA.
AC   E9PEC3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Propionyl-CoA carboxylase beta chain, mitochondrial {ECO:0000313|Ensembl:ENSP00000417253};
GN   Name=PCCB {ECO:0000313|Ensembl:ENSP00000417253};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417253, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000417253, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000417253}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC069524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PEC3; -.
DR   jPOST; E9PEC3; -.
DR   MaxQB; E9PEC3; -.
DR   PeptideAtlas; E9PEC3; -.
DR   PRIDE; E9PEC3; -.
DR   Ensembl; ENST00000482086; ENSP00000417253; ENSG00000114054.
DR   UCSC; uc062ocz.1; human.
DR   EuPathDB; HostDB:ENSG00000114054.13; -.
DR   HGNC; HGNC:8654; PCCB.
DR   OpenTargets; ENSG00000114054; -.
DR   eggNOG; KOG0540; Eukaryota.
DR   eggNOG; COG4799; LUCA.
DR   GeneTree; ENSGT00940000157741; -.
DR   ChiTaRS; PCCB; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000114054; Expressed in 222 organ(s), highest expression level in right adrenal gland.
DR   ExpressionAtlas; E9PEC3; baseline and differential.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   InterPro; IPR034733; AcCoA_carboxyl.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   SUPFAM; SSF52096; SSF52096; 2.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PEC3,
KW   ECO:0000213|MaxQB:E9PEC3, ECO:0000213|PeptideAtlas:E9PEC3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    423       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242785.
FT   DOMAIN        1    174       CoA carboxyltransferase N-terminal.
FT                                {ECO:0000259|PROSITE:PS50980}.
FT   DOMAIN      178    417       CoA carboxyltransferase C-terminal.
FT                                {ECO:0000259|PROSITE:PS50989}.
SQ   SEQUENCE   423 AA;  45421 MW;  5D426A16C7FAA922 CRC64;
     MAAALRVAAV GARLSVLASG LRAAVRSLCS QAITVGAPVI GLNDSGGARI QEGVESLAGY
     ADIFLRNVTA SGVIPQISLI MGPCAGGAVY SPALTDFTFM VKDTSYLFIT GPDVVKSVTN
     EDVTQEELGG AKTHTTMSGV AHRAFENDVD ALCNLRDFFN YLPLSSQDPA PVRECHDPSD
     RLVPELDTIV PLESTKAYNM VDIIHSVVDE REFFEIMPNY AKNIIVGFAR MNGRTVGIVG
     NQPKVASGCL DINSSVKGAR FVRFCDAFNI PLITFVDVPG FLPGTAQEYG GIIRHGAKLL
     YAFAEATVPK VTVITRKAYG GAYDVMSSKH LCGDTNYAWP TAEIAVMGAK GAVEIIFKGH
     ENVEAAQAEY IEKFANPFPA AVRGFVDDII QPSSTRARIC CDLDVLASKK VQRPWRKHAN
     IPL
//