ID E9PDY4_HUMAN Unreviewed; 2489 AA. AC E9PDY4; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 16-JAN-2019, entry version 61. DE SubName: Full=Complement receptor type 1 {ECO:0000313|Ensembl:ENSP00000356016}; GN Name=CR1 {ECO:0000313|Ensembl:ENSP00000356016}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356016, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000356016, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., RA Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000356016} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL137789; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL691452; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_000642.3; NM_000651.4. DR UniGene; Hs.334019; -. DR ProteinModelPortal; E9PDY4; -. DR SMR; E9PDY4; -. DR jPOST; E9PDY4; -. DR PeptideAtlas; E9PDY4; -. DR PRIDE; E9PDY4; -. DR Ensembl; ENST00000367049; ENSP00000356016; ENSG00000203710. DR GeneID; 1378; -. DR UCSC; uc001hfx.4; human. DR CTD; 1378; -. DR EuPathDB; HostDB:ENSG00000203710.10; -. DR HGNC; HGNC:2334; CR1. DR OpenTargets; ENSG00000203710; -. DR eggNOG; ENOG410KDF5; Eukaryota. DR eggNOG; ENOG410YE3Q; LUCA. DR GeneTree; ENSGT00940000160375; -. DR OMA; CTPPDVE; -. DR OrthoDB; 46968at2759; -. DR PhylomeDB; E9PDY4; -. DR TreeFam; TF316872; -. DR ChiTaRS; CR1; human. DR GenomeRNAi; 1378; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000203710; Expressed in 135 organ(s), highest expression level in blood. DR ExpressionAtlas; E9PDY4; baseline and differential. DR Genevisible; E9PDY4; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR CDD; cd00033; CCP; 37. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR Pfam; PF00084; Sushi; 37. DR SMART; SM00032; CCP; 37. DR SUPFAM; SSF57535; SSF57535; 37. DR PROSITE; PS50923; SUSHI; 37. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302, KW ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:E9PDY4, KW ECO:0000213|PeptideAtlas:E9PDY4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 41 {ECO:0000256|SAM:SignalP}. FT CHAIN 42 2489 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003244036. FT TRANSMEM 2422 2446 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 41 101 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 102 163 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 164 234 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 236 293 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 295 355 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 356 418 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 419 489 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 491 551 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 552 613 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 614 684 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 686 743 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 745 805 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 806 868 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 869 939 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 941 1001 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1002 1063 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1064 1134 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1136 1193 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1195 1255 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1256 1318 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1319 1389 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1391 1451 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1452 1513 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1514 1584 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1586 1643 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1645 1705 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1706 1768 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1769 1839 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1844 1904 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1905 1966 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1967 2037 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2039 2096 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2098 2158 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2159 2221 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2222 2292 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2296 2356 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2357 2417 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DISULFID 43 86 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 266 293 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 297 340 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 326 353 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 493 536 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 716 743 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 747 790 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 776 803 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 943 986 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1166 1193 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1197 1240 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1226 1253 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1393 1436 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1616 1643 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1647 1690 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1676 1703 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1846 1889 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2069 2096 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2100 2143 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2129 2156 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2298 2341 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2327 2354 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2359 2402 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2388 2415 {ECO:0000256|PROSITE-ProRule:PRU00302}. SQ SEQUENCE 2489 AA; 272924 MW; B80E2DBF555E6B54 CRC64; MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TITNGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN TAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNLGSR GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA PRCAVKSCDD FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC VLVGMRSLWN NSVPVCEHIF CPNPPAILNG RHTGTPSGDI PYGKEISYTC DPHPDRGMTF NLIGESTIRC TSDPHGNGVW SSPAPRCELS VRAGHCKTPE QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL ENLVWSSVED NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT GPDGEQLFEL VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI RVPGNRSFFT LTEIIRFRCQ PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC QPPPEILHGE HTLSHQDNFS PGQEVFYSCE PSYDLRGAAS LHCTPQGDWS PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD EGFRLKGRSA SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH PPKIQNGHYI GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL DHYCKEVNCS FPLFMNGISK ELEMKKVYHY GDYVTLKCED GYTLEGSPWS QCQADDRWDP PLAKCTSRTH DALIVGTLSG TIFFILLIIF LSWIILKHRK GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP //