ID   E9PDS3_HUMAN            Unreviewed;       632 AA.
AC   E9PDS3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   13-FEB-2019, entry version 61.
DE   SubName: Full=Integrin alpha-9 {ECO:0000313|Ensembl:ENSP00000397258};
GN   Name=ITGA9 {ECO:0000313|Ensembl:ENSP00000397258};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000397258, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000397258, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000397258}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC       {ECO:0000256|SAAS:SAAS01130326}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00534092}.
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DR   EMBL; AC092055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP006240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PDS3; -.
DR   jPOST; E9PDS3; -.
DR   PeptideAtlas; E9PDS3; -.
DR   PRIDE; E9PDS3; -.
DR   Ensembl; ENST00000422441; ENSP00000397258; ENSG00000144668.
DR   UCSC; uc003chc.4; human.
DR   EuPathDB; HostDB:ENSG00000144668.11; -.
DR   HGNC; HGNC:6145; ITGA9.
DR   OpenTargets; ENSG00000144668; -.
DR   eggNOG; KOG3637; Eukaryota.
DR   eggNOG; ENOG410XPVZ; LUCA.
DR   GeneTree; ENSGT00940000156503; -.
DR   ChiTaRS; ITGA9; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000144668; Expressed in 192 organ(s), highest expression level in testis.
DR   ExpressionAtlas; E9PDS3; baseline and differential.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SUPFAM; SSF69179; SSF69179; 1.
DR   PROSITE; PS51470; FG_GAP; 7.
PE   1: Evidence at protein level;
KW   Cell adhesion {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS01101218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Integrin {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494682};
KW   Membrane {ECO:0000256|SAAS:SAAS00494657};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PDS3,
KW   ECO:0000213|PeptideAtlas:E9PDS3};
KW   Receptor {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS01101220};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00504086};
KW   Signal {ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00494657};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00494657}.
FT   SIGNAL        1     31       {ECO:0000256|RuleBase:RU003762}.
FT   CHAIN        32    632       {ECO:0000256|RuleBase:RU003762}.
FT                                /FTId=PRO_5001424266.
FT   REPEAT       35     96       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      111    174       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      182    232       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      233    289       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      290    349       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      351    408       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      411    474       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   DOMAIN      459    611       Integrin_alpha2.
FT                                {ECO:0000259|Pfam:PF08441}.
SQ   SEQUENCE   632 AA;  69081 MW;  08D5BF65AC9B68C1 CRC64;
     MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY AVLEHFHDNT
     RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL DMARGKNRGT SCGKTCREDR
     DDEWMGVSLA RQPKADGRVL ACAHRWKNIY YEADHILPHG FCYIIPSNLQ AKGRTLIPCY
     EEYKKKYGEE HGSCQAGIAG FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM
     NRRYTYLGYA VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM
     GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE QLALTGDGAY
     NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH GDAGGIVPQY SMKLSGQKIN
     PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM SDSVVLLRAR PVITVDVSIF LPGSINITAP
     QCHDGQQPVN CLNVTTCFSF HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG
     QVTEKLQLTY MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL
     RWKKGQKIAQ KNQVRTLKLI LSTQGGSCTE QK
//