ID   E9PDN6_HUMAN            Unreviewed;      1311 AA.
AC   E9PDN6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 74.
DE   SubName: Full=Contactin-associated protein-like 4 {ECO:0000313|Ensembl:ENSP00000417628};
GN   Name=CNTNAP4 {ECO:0000313|Ensembl:ENSP00000417628};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417628, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000417628, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000417628}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AC010528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FO681478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PDN6; -.
DR   jPOST; E9PDN6; -.
DR   PeptideAtlas; E9PDN6; -.
DR   PRIDE; E9PDN6; -.
DR   Ensembl; ENST00000476707; ENSP00000417628; ENSG00000152910.
DR   UCSC; uc002fex.2; human.
DR   EuPathDB; HostDB:ENSG00000152910.18; -.
DR   HGNC; HGNC:18747; CNTNAP4.
DR   OpenTargets; ENSG00000152910; -.
DR   eggNOG; KOG3516; Eukaryota.
DR   eggNOG; ENOG410XPHG; LUCA.
DR   GeneTree; ENSGT00940000157674; -.
DR   OMA; CNCANTG; -.
DR   OrthoDB; 338397at2759; -.
DR   PhylomeDB; E9PDN6; -.
DR   ChiTaRS; CNTNAP4; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000152910; Expressed in 96 organ(s), highest expression level in C1 segment of cervical spinal cord.
DR   ExpressionAtlas; E9PDN6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00057; FA58C; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR028875; CASPR4.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   PANTHER; PTHR43925:SF2; PTHR43925:SF2; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF02210; Laminin_G_2; 4.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00282; LamG; 4.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PDN6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00966518};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20   1311       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244031.
FT   TRANSMEM   1244   1268       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    180       F5/8 type C.
FT                                {ECO:0000259|PROSITE:PS50022}.
FT   DOMAIN      186    367       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      373    550       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      552    589       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      588    639       Fibrinogen C-terminal.
FT                                {ECO:0000259|PROSITE:PS51406}.
FT   DOMAIN      796    961       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      962   1000       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1012   1205       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DISULFID    934    961       {ECO:0000256|PROSITE-ProRule:PRU00122}.
SQ   SEQUENCE   1311 AA;  145618 MW;  2A92B65892B6208B CRC64;
     MLLFYLLVVL SIDSTKASAL TNPNVALFLL ADDCDDPLVS ALPQASFSSS SELSSSHGPG
     FARLNRRDGA GGWSPLVSNK YQWLQIDLGE RMEVTAVATQ GGYGSSNWVT SYLLMFSDSG
     WNWKQYRQED SIWGFSGNAN ADSVVYYRLQ PSIKARFLRF IPLEWNPKGR IGMRIEVFGC
     AYRSEVVDLD GKSSLLYRFD QKSLSPIKDI ISLKFKTMQS DGILLHREGP NGDHITLQLR
     RARLFLLINS GEAKLPSTST LVNLTLGSLL DDQHWHSVLI QRLGKQVNFT VDEHRHHFHA
     RGEFNLMNLD YEISFGGIPA PGKSVSFPHR NFHGCLENLY YNGVDIIDLA KQQKPQIIAM
     GNVSFSCSQP QSMPVTFLSS RSYLALPDFS GEEEVSATFQ FRTWNKAGLL LFSELQLISG
     GILLFLSDGK LKSNLYQPGK LPSDITAGVE LNDGQWHSVS LSAKKNHLSV AVDGQMASAA
     PLLGPEQIYS GGTYYFGGCP DKSFGSKCKS PLGGFQGCMR LISISGKVVD LISVQQGSLG
     NFSDLQIDSC GISDRCLPNY CEHGGECSQS WSTFHCNCTN TGYRGATCHN SIYEQSCEAY
     KHRGNTSGFY YIDSDGSGPL EPFLLYCNMT ETAWTIIQHN GSDLTRVRNT NPENPYAGFF
     EYVASMEQLQ ATINRAEHCE QEFTYYCKKS RLVNKQDGTP LSWWVGRTNE TQTYWGGSSP
     DLQKCTCGLE GNCIDSQYYC NCDADRNEWT NDTGLLAYKE HLPVTKIVIT DTGRLHSEAA
     YKLGPLLCQG DRSFWNSASF DTEASYLHFP TFHGELSADV SFFFKTTASS GVFLENLGIA
     DFIRIELRSP TVVTFSFDVG NGPFEISVQS PTHFNDNQWH HVRVERNMKE ASLQVDQLTP
     KTQPAPADGH VLLQLNSQLF VGGTATRQRG FLGCIRSLQL NGMTLDLEER AQVTPEVQPG
     CRGHCSSYGK LCRNGGKCRE RPIGFFCDCT FSAYTGPFCS NEISAYFGSG SSVIYNFQEN
     YLLSKNSSSH AASFHGDMKL SREMIKFSFR TTRTPSLLLF VSSFYKEYLS VIIAKNGSLQ
     IRYKLNKYQE PDVVNFDFKN MADGQLHHIM INREEGVVFI EIDDNRRRQV HLSSGTEFSA
     VKSLVLGRIL EHSDVDQDTA LAGAQGFTGC LSAVQLSHVA PLKAALHPSH PDPVTVTGHV
     TESSCMAQPG TDATSRERTH SFADHSGTID DREPLANAIK SDSAVIGGLI AVVIFILLCI
     TAIAVRIYQQ KRLYKRSEAK RSENVDSAEA VLKSELNIQN AVNENQKEYF F
//