ID   E9PDG3_HUMAN            Unreviewed;       580 AA.
AC   E9PDG3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=WD repeat-containing protein 81 {ECO:0000313|Ensembl:ENSP00000401560};
GN   Name=WDR81 {ECO:0000313|Ensembl:ENSP00000401560};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401560, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000401560, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000401560}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000481723}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC130343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC206360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E9PDG3; -.
DR   MaxQB; E9PDG3; -.
DR   PeptideAtlas; E9PDG3; -.
DR   PRIDE; E9PDG3; -.
DR   Ensembl; ENST00000446363; ENSP00000401560; ENSG00000167716.
DR   Ensembl; ENST00000615141; ENSP00000481723; ENSG00000276021.
DR   UCSC; uc059zis.1; human.
DR   EuPathDB; HostDB:ENSG00000167716.18; -.
DR   HGNC; HGNC:26600; WDR81.
DR   OpenTargets; ENSG00000167716; -.
DR   eggNOG; KOG1786; Eukaryota.
DR   eggNOG; KOG4190; Eukaryota.
DR   eggNOG; ENOG410XR4I; LUCA.
DR   GeneTree; ENSGT00930000151039; -.
DR   SignaLink; E9PDG3; -.
DR   ChiTaRS; WDR81; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000167716; Expressed in 191 organ(s), highest expression level in quadriceps femoris.
DR   ExpressionAtlas; E9PDG3; baseline and differential.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PDG3,
KW   ECO:0000213|MaxQB:E9PDG3, ECO:0000213|PeptideAtlas:E9PDG3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    580       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014089022.
FT   DOMAIN      283    503       WD_REPEATS_REGION.
FT                                {ECO:0000259|PROSITE:PS50294}.
FT   REPEAT      283    314       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
SQ   SEQUENCE   580 AA;  62689 MW;  8ED5203FD2D85E4A CRC64;
     MDILPRISHE VLLPVLSFLT SLVTGFPSGA QARTILCVKT ISLIALICLR IGQEMVQQHL
     SEPVATFFQV FSQLHELRQQ DLKLDPAGRG EGQLPQVVFS DGQQRPVDPA LLDELQKVFT
     LEMAYTIYVP FSCLLGDIIR KIIPNHELVG ELAALYLESI SPSSRNPASV EPTMPGTGPE
     WDPHGGGCPQ DDGHSGTFGS VLVGNRIQIP NDSRPENPGP LGPISGVGGG GLGSGSDDNA
     LKQELPRSVH GLSGNWLAYW QYEIGVSQQD AHFHFHQIRL QSFPGHSGAV KCVAPLSSED
     FFLSGSKDRT VRLWPLYNYG DGTSETAPRL VYTQHRKSVF FVGQLEAPQH VVSCDGAVHV
     WDPFTGKTLR TVEPLDSRVP LTAVAVMPAP HTSITMASSD STLRFVDCRK PGLQHEFRLG
     GGLNPGLVRA LAISPSGRSV VAGFSSGFMV LLDTRTGLVL RGWPAHEGDI LQIKAVEGSV
     LVSSSSDHSL TVWKELEQKP THHYKSASDP IHTFDLYGSE VVTGTVSNKI GVCSLLEPPS
     QATTKLSSEN FRGTLTSLAL LPTKRHLLLG SDNGVIRLLA
//