ID   E9PD17_HUMAN            Unreviewed;       402 AA.
AC   E9PD17;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   Name=UGT3A1 {ECO:0000313|Ensembl:ENSP00000426100};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426100, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426100, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426100}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059};
CC       Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|RuleBase:RU003718, ECO:0000256|SAAS:SAAS00846206}.
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DR   EMBL; AC016612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PD17; -.
DR   EPD; E9PD17; -.
DR   jPOST; E9PD17; -.
DR   PeptideAtlas; E9PD17; -.
DR   PRIDE; E9PD17; -.
DR   Ensembl; ENST00000507113; ENSP00000426100; ENSG00000145626.
DR   UCSC; uc011cor.3; human.
DR   EuPathDB; HostDB:ENSG00000145626.11; -.
DR   HGNC; HGNC:26625; UGT3A1.
DR   OpenTargets; ENSG00000145626; -.
DR   GeneTree; ENSGT00940000163740; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000145626; Expressed in 48 organ(s), highest expression level in kidney epithelium.
DR   ExpressionAtlas; E9PD17; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU003718};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PD17};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|RuleBase:RU003718}.
FT   SIGNAL        1     22       {ECO:0000256|RuleBase:RU362059}.
FT   CHAIN        23    402       UDP-glucuronosyltransferase.
FT                                {ECO:0000256|RuleBase:RU362059}.
FT                                /FTId=PRO_5005128612.
FT   DOMAIN      317    360       UDPGT. {ECO:0000259|PROSITE:PS00375}.
SQ   SEQUENCE   402 AA;  45612 MW;  05BE6B90E0D857EE CRC64;
     MVGQRVLLLV AFLLSGVLLS EAAKILTIST LDIKEEEKSY QVIRWFSPED HQKRIKKHFD
     SYIETALDGR KESEALVKLM EIFGTQCSYL LSRKDIMDSL KNENYDLVFV EAFDFCSFLI
     AEKLVKPFVA ILPTTFGSLD FGLPSPLSYV PVFPSLLTDH MDFWGRVKNF LMFFSFSRSQ
     WDMQSTFDNT IKEHFPEGSR PVLSHLLLKA ELWFVNSDFA FDFARPLLPN TVYIGGLMEK
     PIKPVPQDLD NFIANFGDAG FVLVAFGSML NTHQSQEVLK KMHNAFAHLP QGVIWTCQSS
     HWPRDVHLAT NVKIVDWLPQ SDLLAHPSIR LFVTHGGQNS VMEAIRHGVP MVGLPVNGDQ
     HGNMVRVVAK NYGVSIRLNQ VTADTLTLTM KQVIEDKRYV AL
//