ID   E9PCT8_HUMAN            Unreviewed;       298 AA.
AC   E9PCT8;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   07-NOV-2018, entry version 45.
DE   SubName: Full=Alpha-sarcoglycan {ECO:0000313|Ensembl:ENSP00000426571};
GN   Name=SGCA {ECO:0000313|Ensembl:ENSP00000426571};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426571, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426571, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426571}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC015909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PCT8; -.
DR   PeptideAtlas; E9PCT8; -.
DR   PRIDE; E9PCT8; -.
DR   Ensembl; ENST00000513821; ENSP00000426571; ENSG00000108823.
DR   UCSC; uc060hfx.1; human.
DR   EuPathDB; HostDB:ENSG00000108823.15; -.
DR   HGNC; HGNC:10805; SGCA.
DR   OpenTargets; ENSG00000108823; -.
DR   eggNOG; KOG4482; Eukaryota.
DR   eggNOG; ENOG4110FPC; LUCA.
DR   GeneTree; ENSGT00390000005672; -.
DR   ChiTaRS; SGCA; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000108823; Expressed in 121 organ(s), highest expression level in gastrocnemius.
DR   ExpressionAtlas; E9PCT8; baseline and differential.
DR   GO; GO:0016012; C:sarcoglycan complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR028658; Alpha-SG.
DR   InterPro; IPR006644; Cadg.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR008908; Sarcoglycan_alpha/epsilon.
DR   PANTHER; PTHR10132; PTHR10132; 1.
DR   PANTHER; PTHR10132:SF16; PTHR10132:SF16; 1.
DR   Pfam; PF05510; Sarcoglycan_2; 1.
DR   SMART; SM00736; CADG; 1.
DR   SUPFAM; SSF49313; SSF49313; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PCT8,
KW   ECO:0000213|PeptideAtlas:E9PCT8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    298       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245105.
FT   DOMAIN       27    131       CADG. {ECO:0000259|SMART:SM00736}.
SQ   SEQUENCE   298 AA;  32796 MW;  1EAF4C445E7498EB CRC64;
     MAETLFWTPL LVVLLAGLGD TEAQQTTLHP LVGRVFVHTL DHETFLSLPE HVAVPPAVHI
     TYHAHLQGHP DLPRWLRYTQ RSPHHPGFLY GSATPEDRGL QVIEVTAYNR DSFDTTRQRL
     VLEIGDPEGP LLPYQAEFLV RSHDAEEVLP STPASRFLSA LGGLWEPGEL QLLNVTSALD
     RGGRVPLPIE GRKEGVYIKV GSASPFSTCL KMVASPDSHA RCAQGQPPLL SCYDTLAPHF
     RVDWCNVTLA EERPGYLRHP DGPPLHHPRE HRGAAADGGQ PRGAPATLHP AHVQCAHR
//