ID   E9PCL8_HUMAN            Unreviewed;        87 AA.
AC   E9PCL8;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Sodium/calcium exchanger 1 {ECO:0000313|Ensembl:ENSP00000389330};
DE   Flags: Fragment;
GN   Name=SLC8A1 {ECO:0000313|Ensembl:ENSP00000389330};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389330, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000389330, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000389330}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000398575}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC007254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E9PCL8; -.
DR   PeptideAtlas; E9PCL8; -.
DR   PRIDE; E9PCL8; -.
DR   Ensembl; ENST00000448531; ENSP00000398575; ENSG00000183023.
DR   Ensembl; ENST00000455476; ENSP00000389330; ENSG00000183023.
DR   UCSC; uc061iob.1; human.
DR   EuPathDB; HostDB:ENSG00000183023.18; -.
DR   HGNC; HGNC:11068; SLC8A1.
DR   OpenTargets; ENSG00000183023; -.
DR   eggNOG; KOG1306; Eukaryota.
DR   eggNOG; ENOG410XPJP; LUCA.
DR   GeneTree; ENSGT00940000155129; -.
DR   ChiTaRS; SLC8A1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000183023; Expressed in 201 organ(s), highest expression level in heart.
DR   ExpressionAtlas; E9PCL8; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR   InterPro; IPR002987; NaCa_exhngr1.
DR   PRINTS; PR01260; NACAEXCHNGR1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PCL8,
KW   ECO:0000213|PeptideAtlas:E9PCL8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     35       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        36     87       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014088975.
FT   NON_TER      87     87       {ECO:0000313|Ensembl:ENSP00000389330}.
SQ   SEQUENCE   87 AA;  9814 MW;  534F4D266D0F1836 CRC64;
     MYNMRRLSLS PTFSMGFHLL VTVSLLFSHV DHVIAETEME GEGNETGECT GSYYCKKGVI
     LPIWEPQDPS FGDKIARATV YFVAMVY
//