ID   E9PCD7_HUMAN            Unreviewed;       958 AA.
AC   E9PCD7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   13-FEB-2019, entry version 58.
DE   SubName: Full=Epididymis-specific alpha-mannosidase {ECO:0000313|Ensembl:ENSP00000423129};
GN   Name=MAN2B2 {ECO:0000313|Ensembl:ENSP00000423129};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000423129, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000423129, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000423129}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC093323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001278967.1; NM_001292038.1.
DR   UniGene; Hs.188464; -.
DR   ProteinModelPortal; E9PCD7; -.
DR   jPOST; E9PCD7; -.
DR   MaxQB; E9PCD7; -.
DR   PeptideAtlas; E9PCD7; -.
DR   PRIDE; E9PCD7; -.
DR   Ensembl; ENST00000504248; ENSP00000423129; ENSG00000013288.
DR   GeneID; 23324; -.
DR   UCSC; uc011bwf.2; human.
DR   CTD; 23324; -.
DR   EuPathDB; HostDB:ENSG00000013288.8; -.
DR   HGNC; HGNC:29623; MAN2B2.
DR   OpenTargets; ENSG00000013288; -.
DR   GeneTree; ENSGT00940000153720; -.
DR   OrthoDB; 201312at2759; -.
DR   ChiTaRS; MAN2B2; human.
DR   GenomeRNAi; 23324; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000013288; Expressed in 229 organ(s), highest expression level in tendon.
DR   ExpressionAtlas; E9PCD7; baseline and differential.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1270.50; -; 2.
DR   Gene3D; 2.60.40.1180; -; 1.
DR   Gene3D; 3.20.110.10; -; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
DR   SUPFAM; SSF88688; SSF88688; 1.
DR   SUPFAM; SSF88713; SSF88713; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PCD7,
KW   ECO:0000213|MaxQB:E9PCD7, ECO:0000213|PeptideAtlas:E9PCD7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    958       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244982.
FT   DOMAIN      305    388       Alpha-mann_mid.
FT                                {ECO:0000259|SMART:SM00872}.
SQ   SEQUENCE   958 AA;  108147 MW;  F010CDED41C8469C CRC64;
     MGQLCWLPLL APLLLLRPPG VQSAGPIRAF VVPHSHMDVG WVYTVQESMR AYAANVYTSV
     VEELARGQQR RFIAVEQEFF RLWWDGVASD QQKYQVRQLL EEGRLEFVIG GQVMHDEAVT
     HLDDQILQLT EGHGFLYETF GIRPQFSWHV DPFGASATTP TLFALAGFNA HLGSRIDYDL
     KAAMQEARGL QFVWRGSPSL SERQEIFTHI MDQYSYCTPS HIPFSNRSGF YWNGVAVFPK
     PPQDGVYPNM SEPVTPANIN LYAELGVSVQ YATLGDYFRA LHALNVTWRV RDHHDFLPYS
     TEPFQAWTGF YTSRSSLKGL ARRASALLYA GESMFTRYLW PAPRGHLDPT WALQQLQQLR
     WAVSEVQHHD AITGTESPKV RDMYATHLAS GMLGMRKLMA SIVLDELQPQ APMAASSDAG
     PAGHFASVYN PLAWTVTTIV TLTVGFPGVR VTDEAGHPVP SQIQNSTETP SAYDLLILTT
     IPGLSYRHYN IRPTAGAQEG TQEPAATVAS TLQFGRRLRR RTSHAGRYLV PVANDCYIVL
     LDQDTNLMHS IWERQSNRTV RVTQEFLEYH VNGDVKQGPI SDNYLFTPGK AAVPAWEAVE
     MEIVAGQLVT EIRQYFYRNM TAQNYTYAIR SRLTHVPQGH DGELLCHRIE QEYQAGPLEL
     NREAVLRTST NLNSQQVIYS DNNGYQMQRR PYVSYVNNSI ARNYYPMVQS AFMEDGKSRL
     VLLSERAHGI SSQGNGQVEV MLHRRLWNNF DWDLGYNLTL NDTSVVHPVL WLLLGSWSLT
     TALRQRSALA LQHRPVVLFG DLAGTAPKLP GPQQQEAVTL PPNLHLQILS IPGWRYSSNH
     TEHSQNLRKG HRGEAQADLR RVLLRLYHLY EVGEDPVLSQ PVTVNLEAVL QALGSVVAVE
     ERSLTGTWDL SMLHRWSWRT GPGRHRGDTT SPSRPPGGPI ITVHPKEIRT FFIHFQQQ
//