ID   E9PCB3_HUMAN            Unreviewed;       110 AA.
AC   E9PCB3; E9PP38;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 2.
DT   16-JAN-2019, entry version 63.
DE   SubName: Full=Cathepsin B {ECO:0000313|Ensembl:ENSP00000436456};
GN   Name=CTSB {ECO:0000313|Ensembl:ENSP00000436456};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436456, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436456, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436456}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|RuleBase:RU362133}.
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DR   EMBL; AC025857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PCB3; -.
DR   jPOST; E9PCB3; -.
DR   MaxQB; E9PCB3; -.
DR   PeptideAtlas; E9PCB3; -.
DR   PRIDE; E9PCB3; -.
DR   Ensembl; ENST00000531551; ENSP00000436456; ENSG00000164733.
DR   UCSC; uc064kho.1; human.
DR   EuPathDB; HostDB:ENSG00000164733.20; -.
DR   HGNC; HGNC:2527; CTSB.
DR   OpenTargets; ENSG00000164733; -.
DR   eggNOG; KOG1543; Eukaryota.
DR   eggNOG; COG4870; LUCA.
DR   GeneTree; ENSGT00940000158680; -.
DR   ChiTaRS; CTSB; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000164733; Expressed in 232 organ(s), highest expression level in thyroid gland.
DR   ExpressionAtlas; E9PCB3; baseline and differential.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:InterPro.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR012599; Propeptide_C1A.
DR   PANTHER; PTHR12411; PTHR12411; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   Pfam; PF08127; Propeptide_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PCB3,
KW   ECO:0000213|MaxQB:E9PCB3, ECO:0000213|PeptideAtlas:E9PCB3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU362133}.
FT   SIGNAL        1     17       {ECO:0000256|RuleBase:RU362133}.
FT   CHAIN        18    110       {ECO:0000256|RuleBase:RU362133}.
FT                                /FTId=PRO_5005397587.
FT   DOMAIN       26     63       Propeptide_C1.
FT                                {ECO:0000259|Pfam:PF08127}.
FT   DOMAIN       80    109       Pept_C1. {ECO:0000259|Pfam:PF00112}.
SQ   SEQUENCE   110 AA;  12682 MW;  B0E9DB72421FE1F4 CRC64;
     MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG
     TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWL
//