ID E9PC35_HUMAN Unreviewed; 1225 AA. AC E9PC35; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 16-JAN-2019, entry version 60. DE SubName: Full=Low-density lipoprotein receptor-related protein 2 {ECO:0000313|Ensembl:ENSP00000409813}; GN Name=LRP2 {ECO:0000313|Ensembl:ENSP00000409813}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409813, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000409813, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000409813} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC007556; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC008178; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PC35; -. DR EPD; E9PC35; -. DR jPOST; E9PC35; -. DR MaxQB; E9PC35; -. DR PeptideAtlas; E9PC35; -. DR PRIDE; E9PC35; -. DR Ensembl; ENST00000443831; ENSP00000409813; ENSG00000081479. DR UCSC; uc010zdf.2; human. DR EuPathDB; HostDB:ENSG00000081479.12; -. DR HGNC; HGNC:6694; LRP2. DR OpenTargets; ENSG00000081479; -. DR GeneTree; ENSGT00940000157232; -. DR ChiTaRS; LRP2; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000081479; Expressed in 129 organ(s), highest expression level in cortex of kidney. DR ExpressionAtlas; E9PC35; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR CDD; cd00112; LDLa; 14. DR Gene3D; 2.120.10.30; -; 3. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF00057; Ldl_recept_a; 13. DR Pfam; PF00058; Ldl_recept_b; 3. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00181; EGF; 10. DR SMART; SM00179; EGF_CA; 1. DR SMART; SM00192; LDLa; 15. DR SMART; SM00135; LY; 7. DR SUPFAM; SSF57184; SSF57184; 1. DR SUPFAM; SSF57424; SSF57424; 15. DR PROSITE; PS01209; LDLRA_1; 7. DR PROSITE; PS50068; LDLRA_2; 15. DR PROSITE; PS51120; LDLRB; 6. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|SAAS:SAAS00590129}; KW Membrane {ECO:0000256|SAAS:SAAS00492819}; KW Proteomics identification {ECO:0000213|MaxQB:E9PC35, KW ECO:0000213|PeptideAtlas:E9PC35}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00998998}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00492819}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00492819}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1225 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003245098. FT DOMAIN 66 104 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 107 143 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 182 218 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 311 347 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 348 386 EGF_CA. {ECO:0000259|SMART:SM00179}. FT DOMAIN 351 386 EGF-like. {ECO:0000259|SMART:SM00181}. FT REPEAT 436 478 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 479 521 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 543 585 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DOMAIN 593 636 EGF-like. {ECO:0000259|SMART:SM00181}. FT REPEAT 659 700 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 701 744 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 745 788 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DOMAIN 836 877 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 929 965 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 971 1007 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 1011 1047 EGF-like. {ECO:0000259|SMART:SM00181}. FT DISULFID 28 40 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 35 53 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 47 62 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 108 120 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 115 133 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 127 142 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 152 170 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 164 179 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 183 195 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 190 208 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 202 217 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 222 234 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 229 247 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 241 256 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 889 901 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 896 914 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 908 923 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 930 942 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 937 955 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 949 964 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 972 984 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 979 997 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 991 1006 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1012 1024 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1019 1037 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1031 1046 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1070 1085 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1134 1146 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1141 1159 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1153 1168 {ECO:0000256|PROSITE-ProRule:PRU00124}. SQ SEQUENCE 1225 AA; 136236 MW; 1884B7553E82D60A CRC64; MDRGPAAVAC TLLLALVACL APASGQECDS AHFRCGSGHC IPADWRCDGT KDCSDDADEI GCAVVTCQQG YFKCQSEGQC IPNSWVCDQD QDCDDGSDER QDCSQSTCSS HQITCSNGQC IPSEYRCDHV RDCPDGADEN DCQYPTCEQL TCDNGACYNT SQKCDWKVDC RDSSDEINCT EICLHNEFSC GNGECIPRAY VCDHDNDCQD GSDEHACNYP TCGGYQFTCP SGRCIYQNWV CDGEDDCKDN GDEDGCESGP HDVHKCSPRE WSCPESGRCI SIYKVCDGIL DCPGREDENN TSTGKYCSMT LCSALNCQYQ CHETPYGGAC FCPPGYIINH NDSRTCVEFD DCQIWGICDQ KCESRPGRHL CHCEEGYILE RGQYCKANDS FGEASIIFSN GRDLLIGDIH GRSFRILVES QNRGVAVGVA FHYHLQRVFW TDTVQNKVFS VDINGLNIQE VLNVSVETPE NLAVDWVNNK IYLVETKVNR IDMVNLDGSY RVTLITENLG HPRGIAVDPT VGKTVVHGGS LIPHPFGVSL FEGQVFFTDW TKMAVLKANK FTETNPQVYY QASLRPYGVT VYHSLRQPYA TNPCKDNNGG CEQVCVLSHR TDNDGLGFRC KCTFGFQLDT DERHCIGREI LAANRVENVE SLAFDWISKN LYWTDSHYKS ISVMRLADKT RRTVVQYLNN PRSVVVHPFA GYLFFTDWFR PAKIMRAWSD GSHLLPVINT TLGWPNGLAI DWAASRLYWV DAYFDKIEHS TFDGLDRRRL GHIEQMTHPF GLAIFGEHLF FTDWRLGAII RVRKADGGEM TVIRSGIAYI LHLKSYDVNI QTGSNACNQP THPNGDCSHF CFPVPNFQRV CGCPYGMRLA SNHLTCEGDP TNEPPTEQCG LFSFPCKNGR CVPNYYLCDG VDDCHDNSDE QLCGTLNNTC SSSAFTCGHG ECIPAHWRCD KRNDCVDGSD EHNCPTHAPA SCLDTQYTCD NHQCISKNWV CDTDNDCGDG SDEKNCNSTE TCQPSQFNCP NHRCIDLSFV CDGDKDCVDG SDEVGCVLNC TASQFKCASG DKCIGVTNRC DGVFDCSDNS DEAGCPTRPP GMCHSDEFQC QEDGICIPNF WECDGHPDCL YGSDEHNACV PKTCPSSYFH CDNGNCIHRA WLCDRDNDCG DMSDEKDCPT QPFRCPSWQW QCLGHNICVN LSVVCDGIFD CPNGTDESPL CSKFPDHSLL AINSF //