ID E9PB77_HUMAN Unreviewed; 641 AA. AC E9PB77; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 16-JAN-2019, entry version 58. DE SubName: Full=Integrin alpha-2 {ECO:0000313|Ensembl:ENSP00000424642}; GN Name=ITGA2 {ECO:0000313|Ensembl:ENSP00000424642}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424642, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000424642, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000424642} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU003762}. CC -!- SIMILARITY: Belongs to the integrin alpha chain family. CC {ECO:0000256|RuleBase:RU003762}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC008966; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC876967; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PB77; -. DR jPOST; E9PB77; -. DR MaxQB; E9PB77; -. DR PeptideAtlas; E9PB77; -. DR PRIDE; E9PB77; -. DR Ensembl; ENST00000509960; ENSP00000424642; ENSG00000164171. DR UCSC; uc063dnf.1; human. DR EuPathDB; HostDB:ENSG00000164171.10; -. DR HGNC; HGNC:6137; ITGA2. DR OpenTargets; ENSG00000164171; -. DR eggNOG; ENOG410IPB9; Eukaryota. DR eggNOG; ENOG4110534; LUCA. DR GeneTree; ENSGT00940000156303; -. DR SignaLink; E9PB77; -. DR ChiTaRS; ITGA2; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000164171; Expressed in 173 organ(s), highest expression level in visceral pleura. DR ExpressionAtlas; E9PB77; baseline and differential. DR GO; GO:0008305; C:integrin complex; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 2.130.10.130; -; 1. DR Gene3D; 3.40.50.410; -; 1. DR InterPro; IPR013517; FG-GAP. DR InterPro; IPR013519; Int_alpha_beta-p. DR InterPro; IPR000413; Integrin_alpha. DR InterPro; IPR028994; Integrin_alpha_N. DR InterPro; IPR002035; VWF_A. DR InterPro; IPR036465; vWFA_dom_sf. DR Pfam; PF01839; FG-GAP; 2. DR Pfam; PF00092; VWA; 1. DR PRINTS; PR01185; INTEGRINA. DR SMART; SM00191; Int_alpha; 4. DR SMART; SM00327; VWA; 1. DR SUPFAM; SSF53300; SSF53300; 1. DR PROSITE; PS51470; FG_GAP; 6. DR PROSITE; PS50234; VWFA; 1. PE 1: Evidence at protein level; KW Cell adhesion {ECO:0000256|RuleBase:RU003762}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Integrin {ECO:0000256|RuleBase:RU003762}; KW Proteomics identification {ECO:0000213|EPD:E9PB77, KW ECO:0000213|MaxQB:E9PB77, ECO:0000213|PeptideAtlas:E9PB77}; KW Receptor {ECO:0000256|RuleBase:RU003762}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00504086}; KW Signal {ECO:0000256|RuleBase:RU003762}. FT SIGNAL 1 29 {ECO:0000256|RuleBase:RU003762}. FT CHAIN 30 641 {ECO:0000256|RuleBase:RU003762}. FT /FTId=PRO_5001424273. FT REPEAT 34 92 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 101 161 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT DOMAIN 174 361 VWFA. {ECO:0000259|PROSITE:PS50234}. FT REPEAT 366 420 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 423 475 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 477 539 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 540 598 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. SQ SEQUENCE 641 AA; 69464 MW; 4935FE4769F75797 CRC64; MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKEGILGQH QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY SQLLCTIISC QTCSFRKSWD PMEPLGAISS TLGGPWMAME I //