ID   E9PB58_HUMAN            Unreviewed;       488 AA.
AC   E9PB58;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Transmembrane protein 108 {ECO:0000313|Ensembl:ENSP00000423338};
GN   Name=TMEM108 {ECO:0000313|Ensembl:ENSP00000423338};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000423338, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000423338, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000423338}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC018472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC055753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PB58; -.
DR   jPOST; E9PB58; -.
DR   PeptideAtlas; E9PB58; -.
DR   PRIDE; E9PB58; -.
DR   Ensembl; ENST00000515826; ENSP00000423338; ENSG00000144868.
DR   UCSC; uc003epj.3; human.
DR   EuPathDB; HostDB:ENSG00000144868.13; -.
DR   HGNC; HGNC:28451; TMEM108.
DR   OpenTargets; ENSG00000144868; -.
DR   eggNOG; ENOG410IEMG; Eukaryota.
DR   eggNOG; ENOG410YCMK; LUCA.
DR   GeneTree; ENSGT00390000000626; -.
DR   ChiTaRS; TMEM108; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000144868; Expressed in 154 organ(s), highest expression level in frontal cortex.
DR   ExpressionAtlas; E9PB58; baseline and differential.
DR   InterPro; IPR031508; TMEM108.
DR   PANTHER; PTHR28673; PTHR28673; 1.
DR   Pfam; PF15759; TMEM108; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PB58};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    488       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244010.
SQ   SEQUENCE   488 AA;  49937 MW;  C4570809B328B9B7 CRC64;
     MKRSLQALYC QLLSFLLILA LTEALAFAIQ EPSPRESLQV LPSGTPPGTM VTAPHSSTRH
     TSVVMLTPNP DGPPSQAAAP MATPTPRAEG HPPTHTISTI AATVTAPHSE SSLSTGPAPA
     AMATTSSKPE GRPRGQAAPT ILLTKPPGAT SRPTTAPPRT TTRRPPRPPG SSRKGAGNSS
     RPVPPAPGGH SRSKEGQRGR NPSSTPLGQK RPLGKIFQIY KGNFTGSVEP EPSTLTPRTP
     LWGYSSSPQP QTVAATTVPS NTSWAPTTTS LGPAKDKPGL RRAAQGGGST FTSQGGTPDA
     TAASGAPVSP QAAPVPSQRP HHGDPQDGPS HSDSWLTVTP GTSRPLSTSS GVFTAATGPT
     PAAFDTSVSA PSQGIPQGAS TTPQAPTHPS RVSESTISGA KEETVATLTM TDRVPSPLST
     VVSTATGNFL NRLVPAGTWK PGTAGNISHV AEGDKPQHRA TICLSKMDIA WVILAISVPI
     SSCSDPIT
//