ID   E9PAL5_HUMAN            Unreviewed;      2611 AA.
AC   E9PAL5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 3.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Collagen alpha-5(VI) chain {ECO:0000313|Ensembl:ENSP00000265379};
GN   Name=COL6A5 {ECO:0000313|Ensembl:ENSP00000265379};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000265379, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000265379, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000265379}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC093004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC117398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF573676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PAL5; -.
DR   jPOST; E9PAL5; -.
DR   PeptideAtlas; E9PAL5; -.
DR   PRIDE; E9PAL5; -.
DR   Ensembl; ENST00000265379; ENSP00000265379; ENSG00000172752.
DR   UCSC; uc062ntv.1; human.
DR   EuPathDB; HostDB:ENSG00000172752.14; -.
DR   HGNC; HGNC:26674; COL6A5.
DR   OpenTargets; ENSG00000172752; -.
DR   eggNOG; KOG3544; Eukaryota.
DR   eggNOG; ENOG410XNMM; LUCA.
DR   GeneTree; ENSGT00940000162990; -.
DR   TreeFam; TF318242; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000172752; Expressed in 38 organ(s), highest expression level in upper lobe of left lung.
DR   ExpressionAtlas; E9PAL5; baseline and differential.
DR   Gene3D; 3.40.50.410; -; 9.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF01391; Collagen; 4.
DR   Pfam; PF00092; VWA; 9.
DR   SMART; SM00327; VWA; 9.
DR   SUPFAM; SSF53300; SSF53300; 10.
DR   PROSITE; PS50234; VWFA; 9.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PAL5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   2611       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244008.
FT   DOMAIN       30    209       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      236    413       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      442    612       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      628    797       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      814    987       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN     1005   1178       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN     1754   1961       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN     1959   2150       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN     2287   2483       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   COILED     2587   2607       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2611 AA;  289456 MW;  E23349DF945FE0C9 CRC64;
     MKILLIIFVL IIWTETLADQ SPGPGPVYAD VVFLVDSSDH LGPKSFPFVK TFINKMINSL
     PIEANKYRVA LAQYSDEFHS EFHLSTFKGR SPMLNHLKKN FQFIGGSLQI GKALQEAHRT
     YFSAPINGRD RKQFPPILVV LASAESEDEV EEASKALQKD GVKIISVGVQ KASEENLKAM
     ATSHFHFNLR TIRDLSTFSQ NMTQIIKDVT KYKEGAVDAD MQVHFPISCQ KDSLADLVFL
     VDESLGTGGN LRHLQTFLEN ITSSMDVKEN CMRLGLMSYS NSAKTISFLK SSTTQSEFQQ
     QIKNLSIQVG KSNTGAAIDQ MRRDGFSESY GSRRAQGVPQ IAVLVTHRPS DDEVHDAALN
     LRLEDVNVFA LSIQGANNTQ LEEIVSYPPE QTISTLKSYA DLETYSTKFL KKLQNEIWSQ
     ISTYAEQRNL DKTGCVDTKE ADIHFLIDGS SSIQEKQFEQ IKRFMLEVTE MFSIGPDKVR
     VGVVQYSDDT EVEFYITDYS NDIDLRKAIF NIKQLTGGTY TGKALDYILQ IIKNGMKDRM
     SKVPCYLIVL TDGMSTDRVV EPAKRLRAEQ ITVHAVGIGA ANKIELQEIA GKEERVSFGQ
     NFDALKSIKN EVVREICAEK GCEDMKADIM FLVDSSWSIG NENFRKMKIF MKNLLTKIQI
     GADKTQIGVV QFSDKTKEEF QLNRYFTQQE ISDAIDRMSL INEGTLTGKA LNFVGQYFTH
     SKGARLGAKK FLILITDGVA QDDVRDPARI LRGKDVTIFS VGVYNANRSQ LEEISGDSSL
     VFHVENFDHL KALERKLIFR VCALHDCKRI TLLDVVFVLD HSGSIKKQYQ DHMINLTIHL
     VKKADVGRDR VQFGALKYSD QPNILFYLNT YSNRSAIIEN LRKRRDTGGN TYTAKALKHA
     NALFTEEHGS RIKQNVKQML IVITDGESHD HDQLNDTALE LRNKGITIFA VGVGKANQKE
     LEGMAGNKNN TIYVDNFDKL KDVFTLVQER MCTEAPEVCH LQEADVIFLC DGSDRVSNSD
     FVTMTTFLSD LIDNFDIQSQ RMKIGMAQFG SNYQSIIELK NSLTKTQWKT QIQNVSKSGG
     FPRIDFALKK VSNMFNLHAG GRRNAGVPQT LVVITSGDPR YDVADAVKTL KDLGICVLVL
     GIGDVYKEHL LPITGNSEKI ITFQDFDKLK NVDVKKRIIR EICQSCGKTN CFMDIVVGFD
     ISTHVQGQPL FQGHPQLESY LPGILEDISS IKGVSCGAGT EAQVSLAFKV NSDQGFPAKF
     QIYQKAVFDS LLQVNVSGPT HLNAQFLRSL WDTFKDKSAS RGQVLLIFSD GLQSESNIML
     ENQSDRLREA GLDALLVVSL NTTAHHEFSS FEFGKRFDYR THLTIGMREL GKKLSQYLGN
     IAERTCCCTF CKCPGIPGPH GTRGLQAMKG SQGLKGSRGH RGEDGNPGVR GDTGPQGDKG
     IAGCPGAWGQ KGLKGFSGPK GGHGDDGIDG LDGEEGCHGF PGIKGEKGDP GSQGSPGSRG
     APGQYGEKGF PGDPGNPGQN NNIKGQKGSK GEQGRQGRSG QKGVQGSPSS RGSRGREGQR
     GLRGVSGEPG NPGPTGTLGA EGLQGPQGSQ GNPGRKGEKG SQGQKGPQGS PGLMGAKGST
     GRPGLLGKKG EPGLPGDLGP VGQTGQRGRQ GDSGIPGYGQ MGRKGVKGPR GFPGDAGQKG
     DIGNPGIPGG PGPKGFRGLA LTVGLKGEEG SRGLPGPPGQ RGIKGMAGQP VYSQCDLIRF
     LREHSLFKNA YPTELVFALD NSYDVTEESF NKTRDIITSI VNDLNIRENN CPVGARVAMV
     SYNSGTSYLI RWSDYNRKKQ LLQQLSQIKY QDTTEPRDVG NAMRFVTRNV FKRTYAGANV
     RRVAVFFSNG QTASRSSIIT ATMEFSALDI SPTVFAFDER VFLEAFGFDN TGTFQVIPVP
     PNGENQTLER LRRCALCYDK CFPNACIREA FLPEDSYMDV VFLIDNSRNI AKDEFKAVKA
     LVSSVIDNFN IASDPLISDS GDRIALLSYS PWESSRRKMG TVKTEFDFIT YDNQLLMKNH
     IQTSFQQLNG EATIGRALLW TTENLFPETP YLRKHKVIFV VSAGENYERK EFVKMMALRA
     KCQGYVIFVI SLGSTRKDDM EELASYPLDQ HLIQLGRIHK PDLNYIAKFL KPFLYSVRRG
     FNQYPPPMLE DACRLINLGG ENIQNDGFQF VTELQEDFLG GNGFIGQELN SGRESPFVKT
     EDNGSDYLVY LPSQMFEPQK LMINYEKDQK SAEIASLTSG HENYGRKEEP DHTYEPGDVS
     LQEYYMDVAF LIDASQRVGS DEFKEVKAFI TSVLDYFHIA PTPLTSTLGD RVAVLSYSPP
     GYMPNTEECP VYLEFDLVTY NSIHQMKHHL QDSQQLNGDV FIGHALQWTI DNVFVGTPNL
     RKNKVIFVIS AGETNSLDKD VLRNVSLRAK CQGYSIFVFS FGPKHNDKEL EELASHPLDH
     HLVQLGRTHK PDWNYIIKFV KPFVHLIRRA INKYPTEDMK ATCVNMTSPN PENGGTENTV
     LLLPGIYEIK TENGDLFDEF DSQAQHLLVL GNNHSSGSET ATDLMQKLYL LFSTEKLAMK
     DKEKAHLEEI SALVVDKQQE KEDKEMEATD I
//