ID   E7EX61_HUMAN            Unreviewed;       129 AA.
AC   E7EX61;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   RecName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase {ECO:0000256|RuleBase:RU361228};
DE            EC=2.4.2.31 {ECO:0000256|RuleBase:RU361228};
DE   AltName: Full=Mono(ADP-ribosyl)transferase {ECO:0000256|RuleBase:RU361228};
DE   Flags: Fragment;
GN   Name=ART3 {ECO:0000313|Ensembl:ENSP00000421431};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421431, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421431, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421431}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-
CC         ribosyl)-L-arginyl-[protein] + nicotinamide;
CC         Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC         COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154,
CC         ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554;
CC         EC=2.4.2.31; Evidence={ECO:0000256|RuleBase:RU361228};
CC   -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase
CC       family. {ECO:0000256|RuleBase:RU361228}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC112719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EX61; -.
DR   jPOST; E7EX61; -.
DR   PeptideAtlas; E7EX61; -.
DR   PRIDE; E7EX61; -.
DR   Ensembl; ENST00000504914; ENSP00000421431; ENSG00000156219.
DR   UCSC; uc062xku.1; human.
DR   EuPathDB; HostDB:ENSG00000156219.16; -.
DR   HGNC; HGNC:725; ART3.
DR   OpenTargets; ENSG00000156219; -.
DR   eggNOG; ENOG410J8VA; Eukaryota.
DR   eggNOG; ENOG411167J; LUCA.
DR   GeneTree; ENSGT00940000153465; -.
DR   ChiTaRS; ART3; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000156219; Expressed in 136 organ(s), highest expression level in biceps brachii.
DR   ExpressionAtlas; E7EX61; baseline and differential.
DR   GO; GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006471; P:protein ADP-ribosylation; IEA:InterPro.
DR   InterPro; IPR000768; ART.
DR   Pfam; PF01129; ART; 1.
DR   PRINTS; PR00970; RIBTRNSFRASE.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU361228};
KW   NAD {ECO:0000256|RuleBase:RU361228};
KW   NADP {ECO:0000256|RuleBase:RU361228};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EX61,
KW   ECO:0000213|PeptideAtlas:E7EX61};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU361228};
KW   Transferase {ECO:0000256|RuleBase:RU361228}.
FT   SIGNAL        1     26       {ECO:0000256|RuleBase:RU361228}.
FT   CHAIN        27    129       NAD(P)(+)--arginine ADP-
FT                                ribosyltransferase.
FT                                {ECO:0000256|RuleBase:RU361228}.
FT                                /FTId=PRO_5005128328.
FT   NON_TER     129    129       {ECO:0000313|Ensembl:ENSP00000421431}.
SQ   SEQUENCE   129 AA;  14998 MW;  91225F4282AE14A8 CRC64;
     MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK
     ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK
     MAGQSREDY
//