ID E7EX59_HUMAN Unreviewed; 570 AA. AC E7EX59; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 16-JAN-2019, entry version 54. DE SubName: Full=Propionyl-CoA carboxylase beta chain, mitochondrial {ECO:0000313|Ensembl:ENSP00000419129}; GN Name=PCCB {ECO:0000313|Ensembl:ENSP00000419129}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419129, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000419129, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000419129} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC069524; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7EX59; -. DR EPD; E7EX59; -. DR jPOST; E7EX59; -. DR MaxQB; E7EX59; -. DR PeptideAtlas; E7EX59; -. DR PRIDE; E7EX59; -. DR Ensembl; ENST00000468777; ENSP00000419129; ENSG00000114054. DR UCSC; uc062ocy.1; human. DR EuPathDB; HostDB:ENSG00000114054.13; -. DR HGNC; HGNC:8654; PCCB. DR OpenTargets; ENSG00000114054; -. DR GeneTree; ENSGT00940000157741; -. DR OMA; CHFSVMA; -. DR PhylomeDB; E7EX59; -. DR ChiTaRS; PCCB; human. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000114054; Expressed in 222 organ(s), highest expression level in right adrenal gland. DR ExpressionAtlas; E7EX59; baseline and differential. DR GO; GO:0016874; F:ligase activity; IEA:InterPro. DR InterPro; IPR034733; AcCoA_carboxyl. DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf. DR InterPro; IPR011763; COA_CT_C. DR InterPro; IPR011762; COA_CT_N. DR Pfam; PF01039; Carboxyl_trans; 2. DR SUPFAM; SSF52096; SSF52096; 2. DR PROSITE; PS50989; COA_CT_CTER; 1. DR PROSITE; PS50980; COA_CT_NTER; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:E7EX59, KW ECO:0000213|MaxQB:E7EX59, ECO:0000213|PeptideAtlas:E7EX59}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 570 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003219034. FT DOMAIN 32 321 CoA carboxyltransferase N-terminal. FT {ECO:0000259|PROSITE:PS50980}. FT DOMAIN 325 564 CoA carboxyltransferase C-terminal. FT {ECO:0000259|PROSITE:PS50989}. SQ SEQUENCE 570 AA; 61654 MW; 7B80E91423327573 CRC64; MAAALRVAAV GARLSVLASG LRAAVRSLCS QATSVNERIE NKRRTALLGG GQRRIDAQHK RGKLTARERI SLLLDPGSFV ESDMFVEHRC ADFGMAADKN KFPGDSVVTG RGRINGRLVY VFSQIRASAM SPRLVSDSWT QAIHLPWPPK VLGLQDFTVF GGSLSGAHAQ KICKIMDQAI TVGAPVIGLN DSGGARIQEG VESLAGYADI FLRNVTASGV IPQISLIMGP CAGGAVYSPA LTDFTFMVKD TSYLFITGPD VVKSVTNEDV TQEELGGAKT HTTMSGVAHR AFENDVDALC NLRDFFNYLP LSSQDPAPVR ECHDPSDRLV PELDTIVPLE STKAYNMVDI IHSVVDEREF FEIMPNYAKN IIVGFARMNG RTVGIVGNQP KVASGCLDIN SSVKGARFVR FCDAFNIPLI TFVDVPGFLP GTAQEYGGII RHGAKLLYAF AEATVPKVTV ITRKAYGGAY DVMSSKHLCG DTNYAWPTAE IAVMGAKGAV EIIFKGHENV EAAQAEYIEK FANPFPAAVR GFVDDIIQPS STRARICCDL DVLASKKVQR PWRKHANIPL //