ID E7EWP9_HUMAN Unreviewed; 869 AA. AC E7EWP9; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 16-JAN-2019, entry version 52. DE SubName: Full=Serine protease inhibitor Kazal-type 5 {ECO:0000313|Ensembl:ENSP00000421519}; DE Flags: Fragment; GN Name=SPINK5 {ECO:0000313|Ensembl:ENSP00000421519}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421519, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000421519, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000421519} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC006524; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC008722; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC116334; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458030; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7EWP9; -. DR jPOST; E7EWP9; -. DR PeptideAtlas; E7EWP9; -. DR PRIDE; E7EWP9; -. DR Ensembl; ENST00000508733; ENSP00000421519; ENSG00000133710. DR UCSC; uc063ikp.1; human. DR EuPathDB; HostDB:ENSG00000133710.15; -. DR HGNC; HGNC:15464; SPINK5. DR OpenTargets; ENSG00000133710; -. DR eggNOG; ENOG410IP0D; Eukaryota. DR eggNOG; ENOG4111TR7; LUCA. DR GeneTree; ENSGT00510000048608; -. DR ChiTaRS; SPINK5; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000133710; Expressed in 130 organ(s), highest expression level in mouth mucosa. DR ExpressionAtlas; E7EWP9; baseline and differential. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR InterPro; IPR002350; Kazal_dom. DR InterPro; IPR036058; Kazal_dom_sf. DR Pfam; PF00050; Kazal_1; 9. DR SMART; SM00280; KAZAL; 12. DR SUPFAM; SSF100895; SSF100895; 12. DR PROSITE; PS00282; KAZAL_1; 1. DR PROSITE; PS51465; KAZAL_2; 12. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:E7EWP9, KW ECO:0000213|PeptideAtlas:E7EWP9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 869 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003217365. FT DOMAIN 72 134 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 136 197 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 200 266 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 272 316 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 342 404 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 412 470 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 471 532 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 542 603 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 607 669 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 682 738 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 749 811 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 824 869 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT COILED 183 203 {ECO:0000256|SAM:Coils}. FT COILED 247 267 {ECO:0000256|SAM:Coils}. FT COILED 318 340 {ECO:0000256|SAM:Coils}. FT COILED 463 483 {ECO:0000256|SAM:Coils}. FT COILED 517 539 {ECO:0000256|SAM:Coils}. FT COILED 788 812 {ECO:0000256|SAM:Coils}. FT NON_TER 869 869 {ECO:0000313|Ensembl:ENSP00000421519}. SQ SEQUENCE 869 AA; 98466 MW; 4582D83200A77894 CRC64; MKIATVSVLL PLALCLIQDA ASKNEDQDKK FFQSLDGIMF INKCATCKMI LEKEAKSQKR ARHLARAPKA TAPTELNCDD FKKGERDGDF ICPDYYEAVC GTDGKTYDNR CALCAENAKT GSQIGVKSEG ECKSSNPEQD VCSAFRPFVR DGRLGCTREN DPVLGPDGKT HGNKCAMCAE LFLKEAENAK REGETRIRRN AEKDFCKEYE KQVRNGRLFC TRESDPVRGP DGRMHGNKCA LCAEIFKQRF SEENSKTDQN LGKAEEKTKV KREIVKLCSQ YQNQAKNGIL FCTRENDPIR GPDGKMHGNL CSMCQAYFQA ENEEKKKAEA RARNKRESGK ATSYAELCSE YRKLVRNGKL ACTRENDPIQ GPDGKVHGNT CSMCEVFFQA EEEEKKKKEG KSRNKRQSKS TASFEELCSE YRKSRKNGRL FCTRENDPIQ GPDGKMHGNT CSMCEAFFQQ EERARAKAKR EAAKEICSEF RDQVRNGTLI CTREHNPVRG PDGKMHGNKC AMCASVFKLE EEEKKNDKEE KGKVEAEKVK REAVQELCSE YRHYVRNGRL PCTRENDPIE GLDGKIHGNT CSMCEAFFQQ EAKEKERAEP RAKVKREAEK ETCDEFRRLL QNGKLFCTRE NDPVRGPDGK THGNKCAMCK AVFQKENEER KRKEEEDQRN AAGHGSSGGG GGNTQDECAE YREQMKNGRL SCTRESDPVR DADGKSYNNQ CTMCKAKLER EAERKNEYSR SRSNGTGSES GKDTCDEFRS QMKNGKLICT RESDPVRGPD GKTHGNKCTM CKEKLEREAA EKKKKEDEDR SNTGERSNTG ERSNDKEDLC REFRSMQRNG KLICTRENNP VRGPYGKMHI NKCAMCQSI //