ID E7EW83_HUMAN Unreviewed; 526 AA. AC E7EW83; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 2. DT 16-JAN-2019, entry version 65. DE SubName: Full=Adhesion G protein-coupled receptor E3 {ECO:0000313|Ensembl:ENSP00000396208}; GN Name=ADGRE3 {ECO:0000313|Ensembl:ENSP00000396208}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396208, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000396208, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000396208} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC {ECO:0000256|SAAS:SAAS00547938}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC022149; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090427; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC135052; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001276088.1; NM_001289159.1. DR UniGene; Hs.658712; -. DR ProteinModelPortal; E7EW83; -. DR PeptideAtlas; E7EW83; -. DR PRIDE; E7EW83; -. DR Ensembl; ENST00000443157; ENSP00000396208; ENSG00000131355. DR GeneID; 84658; -. DR UCSC; uc010xnv.4; human. DR CTD; 84658; -. DR EuPathDB; HostDB:ENSG00000131355.14; -. DR HGNC; HGNC:23647; ADGRE3. DR OpenTargets; ENSG00000131355; -. DR eggNOG; KOG4193; Eukaryota. DR eggNOG; ENOG410XSD2; LUCA. DR GeneTree; ENSGT00940000163037; -. DR OrthoDB; 124090at2759; -. DR ChiTaRS; ADGRE3; human. DR GenomeRNAi; 84658; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000131355; Expressed in 50 organ(s), highest expression level in leukocyte. DR ExpressionAtlas; E7EW83; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR InterPro; IPR017981; GPCR_2-like. DR InterPro; IPR001740; GPCR_2_EMR1-like_rcpt. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR017983; GPCR_2_secretin-like_CS. DR InterPro; IPR000203; GPS. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF01825; GPS; 1. DR PRINTS; PR01128; EMR1HORMONER. DR PRINTS; PR00249; GPCRSECRETIN. DR SMART; SM00303; GPS; 1. DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. DR PROSITE; PS50221; GPS; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:E7EW83, KW ECO:0000213|PeptideAtlas:E7EW83}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 526 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003217361. FT TRANSMEM 232 255 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 267 284 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 296 320 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 340 360 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 380 404 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 424 446 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 452 475 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 175 224 GPS. {ECO:0000259|PROSITE:PS50221}. FT DOMAIN 230 476 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. SQ SEQUENCE 526 AA; 58396 MW; 1C6B358A321BE750 CRC64; MQGPLLLPGL CFLLSLFGAV TQKTKTSCAK CPPNASCVNN THCTCNHGYT SGSGQKLFTF PLETCNAIET QAITDNCSEE RKTFNLNVQM NSMDIRCSDI IQGDTQGPSA IAFISYSSLG NIINATFFEE MDKKDQVYLN SQVVSAAIGP KRNVSLSKSV TLTFQHVKMT PSTKKVFCVY WKSTGQGSQW SRDGCFLIHV NKSHTMCNCS HLSSFAVLMA LTSQEEDPVL TVITYVGLSV SLLCLLLAAL TFLLCKAIRN TSTSLHLQLS LCLFLAHLLF LVGIDRTEPK VLCSIIAGAL HYLYLAAFTW MLLEGVHLFL TARNLTVVNY SSINRLMKWI MFPVGYGVPA VTVAISAASW PHLYGTADRC WLHLDQGFMW SFLGPVCAIF SANLVLFILV FWILKRKLSS LNSEVSTIQN TRMLAFKATA QLFILGCTWC LGLLQVGPAA QVMAYLFTII NSLQGFFIFL VYCLLSQQVQ KQYQKWFREI VKSKSESETY TLSSKMGPDS KPSEGDVFPG QVKRKY //