ID   E7EVQ3_HUMAN            Unreviewed;       459 AA.
AC   E7EVQ3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 63.
DE   SubName: Full=Angiopoietin-2 {ECO:0000313|Ensembl:ENSP00000428023};
GN   Name=ANGPT2 {ECO:0000313|Ensembl:ENSP00000428023};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428023, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428023, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428023}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC018398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EVQ3; -.
DR   jPOST; E7EVQ3; -.
DR   PeptideAtlas; E7EVQ3; -.
DR   PRIDE; E7EVQ3; -.
DR   Ensembl; ENST00000523120; ENSP00000428023; ENSG00000091879.
DR   UCSC; uc003wql.6; human.
DR   EuPathDB; HostDB:ENSG00000091879.13; -.
DR   HGNC; HGNC:485; ANGPT2.
DR   OpenTargets; ENSG00000091879; -.
DR   eggNOG; KOG2579; Eukaryota.
DR   eggNOG; ENOG410ZYS4; LUCA.
DR   GeneTree; ENSGT00940000158430; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000091879; Expressed in 169 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; E7EVQ3; baseline and differential.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 3.90.215.10; -; 1.
DR   Gene3D; 4.10.530.10; -; 1.
DR   InterPro; IPR028844; Ang-2.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR014715; Fibrinogen_a/b/g_C_2.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   PANTHER; PTHR19143:SF199; PTHR19143:SF199; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00991924};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EVQ3,
KW   ECO:0000213|PeptideAtlas:E7EVQ3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    459       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217569.
FT   DOMAIN      274    443       Fibrinogen C-terminal.
FT                                {ECO:0000259|PROSITE:PS51406}.
FT   COILED      167    201       {ECO:0000256|SAM:Coils}.
FT   COILED      213    247       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   459 AA;  52623 MW;  E4DA5E8470A37468 CRC64;
     MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM DNCRSSSSPY
     VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY IQDNMKKEMV EIQQNAVQNQ
     TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL NQTTRLELQL LEHSLSTNKL EKQILDQTSE
     INKLQDKNSF LEKKVLAMED KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN
     NSVLQKQQHD LMETVNNLLT MMSTSNSKDP TVAKEEQISF RDCAEVFKSG HTTNGIYTLT
     FPNSTEEIKA YCDMEAGGGG WTIIQRREDG SVDFQRTWKE YKVGFGNPSG EYWLGNEFVS
     QLTNQQRYVL KIHLKDWEGN EAYSLYEHFY LSSEELNYRI HLKGLTGTAG KISSISQPGN
     DFSTKDGDND KCICKCSQML TGGRDDFLSS YLYWQGMIS
//