ID   E7EVP0_HUMAN            Unreviewed;       154 AA.
AC   E7EVP0;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   12-SEP-2018, entry version 46.
DE   SubName: Full=Prepronociceptin {ECO:0000313|Ensembl:ENSP00000428059};
DE   Flags: Fragment;
GN   Name=PNOC {ECO:0000313|Ensembl:ENSP00000428059};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428059, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428059, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428059}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU004400}.
CC   -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC       {ECO:0000256|RuleBase:RU004400}.
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DR   EMBL; AC021678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   MaxQB; E7EVP0; -.
DR   PeptideAtlas; E7EVP0; -.
DR   PRIDE; E7EVP0; -.
DR   Ensembl; ENST00000518479; ENSP00000428059; ENSG00000168081.
DR   UCSC; uc064lnr.1; human.
DR   EuPathDB; HostDB:ENSG00000168081.8; -.
DR   HGNC; HGNC:9163; PNOC.
DR   OpenTargets; ENSG00000168081; -.
DR   eggNOG; ENOG410IY0N; Eukaryota.
DR   eggNOG; ENOG4111JDY; LUCA.
DR   GeneTree; ENSGT00510000049153; -.
DR   ChiTaRS; PNOC; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000168081; Expressed in 120 organ(s), highest expression level in anterior cingulate cortex.
DR   ExpressionAtlas; E7EVP0; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002367; Nociceptin.
DR   InterPro; IPR006024; Opioid_neupept.
DR   PANTHER; PTHR11438; PTHR11438; 1.
DR   Pfam; PF01160; Opiods_neuropep; 1.
DR   PRINTS; PR01028; OPIOIDPRCRSR.
DR   PRINTS; PR01031; ORPHNNPRCRSR.
DR   PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU004400};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Neuropeptide {ECO:0000256|RuleBase:RU004400};
KW   Opioid peptide {ECO:0000256|RuleBase:RU004400};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EVP0,
KW   ECO:0000213|PeptideAtlas:E7EVP0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    154       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219329.
FT   NON_TER     154    154       {ECO:0000313|Ensembl:ENSP00000428059}.
SQ   SEQUENCE   154 AA;  17698 MW;  FC70F898DCDA32CC CRC64;
     MKVLLCDLLL LSLFSSVFSS CQRDCLTCQE KLHPALDSFD LEVCILECEE KVFPSPLWTP
     CTKVMARSSW QLSPAAPEHV AAALYQPRAS EMQHLRRMPR VRSLFQEQEE PEPGMEEAGE
     MEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMR
//