ID   E7EV71_HUMAN            Unreviewed;      1353 AA.
AC   E7EV71;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 2.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=Latent-transforming growth factor beta-binding protein 1 {ECO:0000313|Ensembl:ENSP00000393057};
GN   Name=LTBP1 {ECO:0000313|Ensembl:ENSP00000393057};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000393057, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000393057, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:18088087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schutz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000393057}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC019127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL133244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EV71; -.
DR   jPOST; E7EV71; -.
DR   MaxQB; E7EV71; -.
DR   PeptideAtlas; E7EV71; -.
DR   PRIDE; E7EV71; -.
DR   Ensembl; ENST00000418533; ENSP00000393057; ENSG00000049323.
DR   UCSC; uc010ymz.3; human.
DR   EuPathDB; HostDB:ENSG00000049323.15; -.
DR   HGNC; HGNC:6714; LTBP1.
DR   OpenTargets; ENSG00000049323; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; ENOG410Z7XK; LUCA.
DR   GeneTree; ENSGT00940000155823; -.
DR   ChiTaRS; LTBP1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000049323; Expressed in 241 organ(s), highest expression level in descending thoracic aorta.
DR   ExpressionAtlas; E7EV71; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 3.90.290.10; -; 4.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR017878; TB_dom.
DR   InterPro; IPR036773; TB_dom_sf.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF07645; EGF_CA; 12.
DR   Pfam; PF00683; TB; 4.
DR   SMART; SM00181; EGF; 16.
DR   SMART; SM00179; EGF_CA; 15.
DR   SUPFAM; SSF57184; SSF57184; 5.
DR   SUPFAM; SSF57581; SSF57581; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 10.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 7.
DR   PROSITE; PS50026; EGF_3; 12.
DR   PROSITE; PS01187; EGF_CA; 6.
DR   PROSITE; PS51364; TB; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EV71,
KW   ECO:0000213|PeptideAtlas:E7EV71};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1353       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219321.
FT   DOMAIN       73    105       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      231    276       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN      300    337       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      351    403       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN      547    584       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      589    630       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      712    752       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      753    793       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      794    834       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      835    875       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      876    917       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      979   1033       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN     1099   1135       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1156   1209       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN     1253   1289       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1294   1338       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID     77     87       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID     95    104       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1353 AA;  148434 MW;  363A411A3C6A782D CRC64;
     MDTKLMCLLF FFSLPPLLVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK GNTTTLISEN
     GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVHG ASVPKLYQHS
     QQPGKALGTH VIHSTHTLPL TVTSQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDGP
     TGQKTKEAQP GQSQVSYQGL PVQKTQTIHS TYSHQQVIPH VYPVAAKTQL GRCFQETIGS
     QCGKALPGLS KQEDCCGTVG TSWGFNKCQK CPKKPSYHGY NQMMECLPGY KRVNNTFCQD
     INECQLQGVC PNGECLNTMG SYRCTCKIGF GPDPTFSSCV PDPPVISEEK GPCYRLVSSG
     RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAAFK EICPGGMGYT VSGVHRRRPI
     HHHVGKGPVF VKPKNTQPVA KSTHPPPLPA KEEPVEALTF SREHGPGVAE PEVATAPPEK
     EIPSLDQEKT KLEPGQPQLS PGISTIHLHP QFPVVIEKTS PPVPVEVAPE ASTSSASQVI
     APTQVTEINE CTVNPDICGA GHCINLPVRY TCICYEGYRF SEQQRKCVDI DECTQVQHLC
     SQGRCENTEG SFLCICPAGF MASEEGTNCI DVDECLRPDV CGEGHCVNTV GAFRCEYCDS
     GYRMTQRGRC EDIDECLNPS TCPDEQCVNS PGSYQCVPCT EGFRGWNGQC LDVDECLEPN
     VCANGDCSNL EGSYMCSCHK GYTRTPDHKH CRDIDECQQG NLCVNGQCKN TEGSFRCTCG
     QGYQLSAAKD QCEDIDECQH RHLCAHGQCR NTEGSFQCVC DQGYRASGLG DHCEDINECL
     EDKSVCQRGD CINTAGSYDC TCPDGFQLDD NKTCQDINEC EHPGLCGPQG ECLNTEGSFH
     CVCQQGFSIS ADGRTCEDVN ECELLSGVCG EAFCENVEGS FLCVCADENQ EYSPMTGQCR
     SRTSTDLDVD VDQPKEEKKE CYYNLNDASL CDNVLAPNVT KQECCCTSGV GWGDNCEIFP
     CPVLGTAEFT EMCPKGKGFV PAGESSSEAG GENYKDADEC LLFGQEICKN GFCLNTRPGY
     ECYCKQGTYY DPVKLQCFDM DECQDPSSCI DGQCVNTEGS YNCFCTHPMV LDASEKRCIR
     PAESNEQIEE TDVYQDLCWE HLSDEYVCSR PLVGKQTTYT ECCCLYGEAW GMQCALCPLK
     DSDDYAQLCN IPVTGRRQPY GRDALVDFSE QYTPEADPYF IQDRFLNSFE ELQAEECGIL
     NGCENGRCVR VQEGYTCDCF DGYHLDTAKM TCVDVNECDE LNNRMSLCKN AKCINTDGSY
     KCLCLPGYVP SDKPNYCTPL NTALNLEKDS DLE
//