ID   E7EV41_HUMAN            Unreviewed;       664 AA.
AC   E7EV41;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Sodium/calcium exchanger 1 {ECO:0000313|Ensembl:ENSP00000386116};
GN   Name=SLC8A1 {ECO:0000313|Ensembl:ENSP00000386116};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386116, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386116, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386116}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC
CC       2.A.19) family. {ECO:0000256|SAAS:SAAS00611730}.
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DR   EMBL; AC007254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EV41; -.
DR   SMR; E7EV41; -.
DR   EPD; E7EV41; -.
DR   jPOST; E7EV41; -.
DR   PeptideAtlas; E7EV41; -.
DR   PRIDE; E7EV41; -.
DR   Ensembl; ENST00000407929; ENSP00000386116; ENSG00000183023.
DR   UCSC; uc061ino.1; human.
DR   EuPathDB; HostDB:ENSG00000183023.18; -.
DR   HGNC; HGNC:11068; SLC8A1.
DR   OpenTargets; ENSG00000183023; -.
DR   eggNOG; KOG1306; Eukaryota.
DR   eggNOG; ENOG410XPJP; LUCA.
DR   GeneTree; ENSGT00940000155129; -.
DR   ChiTaRS; SLC8A1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000183023; Expressed in 201 organ(s), highest expression level in heart.
DR   ExpressionAtlas; E7EV41; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 2.60.40.2030; -; 2.
DR   InterPro; IPR038081; CalX-like_sf.
DR   InterPro; IPR003644; Calx_beta.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR004836; Na_Ca_Ex.
DR   InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR   InterPro; IPR002987; NaCa_exhngr1.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   Pfam; PF03160; Calx-beta; 2.
DR   Pfam; PF01699; Na_Ca_ex; 1.
DR   Pfam; PF16494; Na_Ca_ex_C; 1.
DR   PRINTS; PR01260; NACAEXCHNGR1.
DR   SMART; SM00237; Calx_beta; 2.
DR   SUPFAM; SSF141072; SSF141072; 2.
DR   TIGRFAMs; TIGR00845; caca; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00087593, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EV41,
KW   ECO:0000213|PeptideAtlas:E7EV41};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00087593,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00087593,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    664       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217344.
FT   TRANSMEM     75     93       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    200    223       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    229    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      302    365       J. {ECO:0000259|PROSITE:PS50076}.
SQ   SEQUENCE   664 AA;  74428 MW;  61CB5387F58FA40F CRC64;
     MRRLSLSPTF SMGFHLLVTV SLLFSHVDHV IAETEMEGEG NETGECTGSY YCKKGVILPI
     WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI EVITSQEKEI TIKKPNGETT
     KTTVRIWNET VSNLTLMALG SSAPEILLSV IEVCGHNFTA GDLGPSTIVG SAAFNMFIII
     ALCVYVVPDG ETRKIKHLRV FFVTAAWSIF AYTWLYIILS VISPGVVEVW EGLLTFFFFP
     ICVVFAWVAD RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP SSKTEIEMDG KVVNSHVENF
     LDGALVLEVD ERDQDDEEAR REMARILKEL KQKHPDKEIE QLIELANYQV LSQQQKSRAF
     YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNTEVTEN DPVSKIFFEQ GTYQCLENCG
     TVALTIIRRG GDLTNTVFVD FRTEDGTANA GSDYEFTEGT VVFKPGDTQK EIRVGIIDDD
     IFEEDENFLV HLSNVKVSSE ASEDGILEAN HVSTLACLGS PSTATVTIFD DDHAGIFTFE
     EPVTHVSESI GIMEVKVLRT SGARGNVIVP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV
     KTISVKVIDD EEYEKNKTFF LEIGEPRLVE MSEKKGRSLP LEYLTVRNMR KSAVSPLCLR
     NQNG
//