ID   E7EUY3_HUMAN            Unreviewed;       516 AA.
AC   E7EUY3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Propionyl-CoA carboxylase beta chain, mitochondrial {ECO:0000313|Ensembl:ENSP00000420391};
GN   Name=PCCB {ECO:0000313|Ensembl:ENSP00000420391};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000420391, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000420391, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000420391}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC069524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EUY3; -.
DR   EPD; E7EUY3; -.
DR   jPOST; E7EUY3; -.
DR   MaxQB; E7EUY3; -.
DR   PeptideAtlas; E7EUY3; -.
DR   PRIDE; E7EUY3; -.
DR   Ensembl; ENST00000462637; ENSP00000420391; ENSG00000114054.
DR   UCSC; uc062ocw.1; human.
DR   EuPathDB; HostDB:ENSG00000114054.13; -.
DR   HGNC; HGNC:8654; PCCB.
DR   OpenTargets; ENSG00000114054; -.
DR   GeneTree; ENSGT00940000157741; -.
DR   ChiTaRS; PCCB; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000114054; Expressed in 222 organ(s), highest expression level in right adrenal gland.
DR   ExpressionAtlas; E7EUY3; baseline and differential.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   InterPro; IPR034733; AcCoA_carboxyl.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   Pfam; PF01039; Carboxyl_trans; 2.
DR   SUPFAM; SSF52096; SSF52096; 2.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E7EUY3,
KW   ECO:0000213|MaxQB:E7EUY3, ECO:0000213|PeptideAtlas:E7EUY3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    516       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217343.
FT   DOMAIN       32    267       CoA carboxyltransferase N-terminal.
FT                                {ECO:0000259|PROSITE:PS50980}.
FT   DOMAIN      271    510       CoA carboxyltransferase C-terminal.
FT                                {ECO:0000259|PROSITE:PS50989}.
SQ   SEQUENCE   516 AA;  55709 MW;  93FE54DC9B0ED4F3 CRC64;
     MAAALRVAAV GARLSVLASG LRAAVRSLCS QATSVNERIE NKRRTALLGG GQRRIDAQHK
     RGKLTARERI SLLLDPGSFV ESDMFVEHRC ADFGMAADKN KDFTVFGGSL SGAHAQKICK
     IMDQAITVGA PVIGLNDSGG ARIQEGVESL AGYADIFLRN VTASGVIPQI SLIMGPCAGG
     AVYSPALTDF TFMVKDTSYL FITGPDVVKS VTNEDVTQEE LGGAKTHTTM SGVAHRAFEN
     DVDALCNLRD FFNYLPLSSQ DPAPVRECHD PSDRLVPELD TIVPLESTKA YNMVDIIHSV
     VDEREFFEIM PNYAKNIIVG FARMNGRTVG IVGNQPKVAS GCLDINSSVK GARFVRFCDA
     FNIPLITFVD VPGFLPGTAQ EYGGIIRHGA KLLYAFAEAT VPKVTVITRK AYGGAYDVMS
     SKHLCGDTNY AWPTAEIAVM GAKGAVEIIF KGHENVEAAQ AEYIEKFANP FPAAVRGFVD
     DIIQPSSTRA RICCDLDVLA SKKVQRPWRK HANIPL
//