ID   E7EUY1_HUMAN            Unreviewed;       356 AA.
AC   E7EUY1;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 66.
DE   SubName: Full=Interferon gamma receptor 2 {ECO:0000313|Ensembl:ENSP00000371425};
GN   Name=IFNGR2 {ECO:0000313|Ensembl:ENSP00000371425};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000371425, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000371425, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
RA   Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
RA   Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
RA   Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
RA   Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
RA   Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
RA   Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
RA   Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
RA   Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
RA   Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
RA   Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
RA   Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000371425}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001316057.1; NM_001329128.1.
DR   UniGene; Hs.634632; -.
DR   ProteinModelPortal; E7EUY1; -.
DR   PeptideAtlas; E7EUY1; -.
DR   PRIDE; E7EUY1; -.
DR   Ensembl; ENST00000381995; ENSP00000371425; ENSG00000159128.
DR   GeneID; 3460; -.
DR   UCSC; uc061zpy.1; human.
DR   CTD; 3460; -.
DR   EuPathDB; HostDB:ENSG00000159128.14; -.
DR   HGNC; HGNC:5440; IFNGR2.
DR   OpenTargets; ENSG00000159128; -.
DR   eggNOG; ENOG410IVC9; Eukaryota.
DR   eggNOG; ENOG410YR1U; LUCA.
DR   GeneTree; ENSGT00940000160503; -.
DR   OMA; PFRVYCL; -.
DR   OrthoDB; 965164at2759; -.
DR   PhylomeDB; E7EUY1; -.
DR   ChiTaRS; IFNGR2; human.
DR   GenomeRNAi; 3460; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000159128; Expressed in 233 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E7EUY1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR   Pfam; PF09294; Interfer-bind; 1.
DR   Pfam; PF01108; Tissue_fac; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    356       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219018.
FT   TRANSMEM    267    290       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      161    259       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
SQ   SEQUENCE   356 AA;  39970 MW;  F18F2FF4A0A29162 CRC64;
     MRPTLLWSLL LLLGVFAAAA AAPPAQLTLE TYQEWCNDSA ATHDPLSQLP APQHPKIRLY
     NAEQVLSWEP VALSNSTRPV VYQVQFKYTD SKWFTADIMS IGVNCTQITA TECDFTAASP
     SAGFPMDFNV TLRLRAELGA LHSAWVTMPW FQHYRNVTVG PPENIEVTPG EGSLIIRFSS
     PFDIADTSTA FFCYYVHYWE KGGIQQVKGP FRSNSISLDN LKPSRVYCLQ VQAQLLWNKS
     NIFRVGHLSN ISCYETMADA STELQQVILI SVGTFSLLSV LAGACFFLVL KYRGLIKYWF
     HTPPSIPLQI EEYLKDPTQP ILEALDKDSS PKDDVWDSVS IISFPEKEQE DVLQTL
//