ID E7EUK6_HUMAN Unreviewed; 438 AA. AC E7EUK6; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 13-FEB-2019, entry version 59. DE SubName: Full=Hepatic triacylglycerol lipase {ECO:0000313|Ensembl:ENSP00000395002}; GN Name=LIPC {ECO:0000313|Ensembl:ENSP00000395002}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395002, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000395002, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000395002} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}. CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase CC family. {ECO:0000256|RuleBase:RU004262, CC ECO:0000256|SAAS:SAAS00591292}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC018904; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC084781; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456063; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7EUK6; -. DR PeptideAtlas; E7EUK6; -. DR PRIDE; E7EUK6; -. DR Ensembl; ENST00000433326; ENSP00000395002; ENSG00000166035. DR UCSC; uc010ugy.3; human. DR EuPathDB; HostDB:ENSG00000166035.10; -. DR HGNC; HGNC:6619; LIPC. DR OpenTargets; ENSG00000166035; -. DR GeneTree; ENSGT00940000157602; -. DR ChiTaRS; LIPC; human. DR Proteomes; UP000005640; Chromosome 15. DR Bgee; ENSG00000166035; Expressed in 87 organ(s), highest expression level in liver. DR ExpressionAtlas; E7EUK6; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro. DR Gene3D; 3.40.50.1820; -; 2. DR InterPro; IPR029058; AB_hydrolase. DR InterPro; IPR013818; Lipase/vitellogenin. DR InterPro; IPR002333; Lipase_hep. DR InterPro; IPR016272; Lipase_LIPH. DR InterPro; IPR001024; PLAT/LH2_dom. DR InterPro; IPR036392; PLAT/LH2_dom_sf. DR InterPro; IPR000734; TAG_lipase. DR PANTHER; PTHR11610; PTHR11610; 2. DR PANTHER; PTHR11610:SF2; PTHR11610:SF2; 2. DR Pfam; PF00151; Lipase; 1. DR Pfam; PF01477; PLAT; 1. DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 2. DR PRINTS; PR00824; HEPLIPASE. DR PRINTS; PR00821; TAGLIPASE. DR SMART; SM00308; LH2; 1. DR SUPFAM; SSF49723; SSF49723; 1. DR SUPFAM; SSF53474; SSF53474; 1. DR PROSITE; PS50095; PLAT; 1. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2}; KW Proteomics identification {ECO:0000213|MaxQB:E7EUK6, KW ECO:0000213|PeptideAtlas:E7EUK6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Secreted {ECO:0000256|SAAS:SAAS00439306}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 438 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003217549. FT DOMAIN 291 425 PLAT. {ECO:0000259|PROSITE:PS50095}. FT ACT_SITE 107 107 Nucleophile. FT {ECO:0000256|PIRSR:PIRSR000865-1}. FT ACT_SITE 133 133 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR000865-1}. FT ACT_SITE 218 218 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR000865-1}. FT METAL 147 147 Calcium; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000865-2}. FT METAL 152 152 Calcium. {ECO:0000256|PIRSR:PIRSR000865- FT 2}. SQ SEQUENCE 438 AA; 49026 MW; A58A6858E271BEA4 CRC64; MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SESVQLSRSH VHLIGYSLGA HVSGFAGSSI GGTHKIGRIT GLDAAGPLFE GSAPSNRLSP DDANFVDAIH TFTREHMGLS VGIKQPIGHY DFYPNGGSFQ PGCHFLELYR HIAQHGFNAI TQTIKCSHER SVHLFIDSLL HAGTQSMAYP CGDMNSFSQG LCLSCKKGRC NTLGYHVRQE PRSKSKRLFL VTRAQSPFKV YHYQFKIQFI NQTETPIQTT FTMSLLGTKE KMQKIPITLG KGIASNKTYS FLITLDVDIG ELIMIKFKWE NSAVWANVWD TVQTIIPWST GPRHSGLVLK TIRVKAGETQ QRMTFCSENT DDLLLRPTQE KIFVKCEIKS KTSKRKIR //