ID E7EUJ1_HUMAN Unreviewed; 499 AA. AC E7EUJ1; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 13-FEB-2019, entry version 64. DE SubName: Full=Hepatic triacylglycerol lipase {ECO:0000313|Ensembl:ENSP00000395569}; GN Name=LIPC {ECO:0000313|Ensembl:ENSP00000395569}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395569, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000395569, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000395569} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}. CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase CC family. {ECO:0000256|RuleBase:RU004262, CC ECO:0000256|SAAS:SAAS00591292}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC018904; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC084781; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456063; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7EUJ1; -. DR jPOST; E7EUJ1; -. DR PeptideAtlas; E7EUJ1; -. DR PRIDE; E7EUJ1; -. DR Ensembl; ENST00000414170; ENSP00000395569; ENSG00000166035. DR UCSC; uc010bfz.2; human. DR EuPathDB; HostDB:ENSG00000166035.10; -. DR HGNC; HGNC:6619; LIPC. DR OpenTargets; ENSG00000166035; -. DR eggNOG; ENOG410IIHP; Eukaryota. DR eggNOG; ENOG4110MCZ; LUCA. DR GeneTree; ENSGT00940000157602; -. DR OMA; AYLCSDM; -. DR PhylomeDB; E7EUJ1; -. DR ChiTaRS; LIPC; human. DR Proteomes; UP000005640; Chromosome 15. DR Bgee; ENSG00000166035; Expressed in 87 organ(s), highest expression level in liver. DR ExpressionAtlas; E7EUJ1; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro. DR CDD; cd00707; Pancreat_lipase_like; 1. DR Gene3D; 3.40.50.1820; -; 1. DR InterPro; IPR029058; AB_hydrolase. DR InterPro; IPR013818; Lipase/vitellogenin. DR InterPro; IPR002333; Lipase_hep. DR InterPro; IPR016272; Lipase_LIPH. DR InterPro; IPR033906; Lipase_N. DR InterPro; IPR001024; PLAT/LH2_dom. DR InterPro; IPR036392; PLAT/LH2_dom_sf. DR InterPro; IPR000734; TAG_lipase. DR PANTHER; PTHR11610; PTHR11610; 1. DR PANTHER; PTHR11610:SF2; PTHR11610:SF2; 1. DR Pfam; PF00151; Lipase; 1. DR Pfam; PF01477; PLAT; 1. DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1. DR PRINTS; PR00824; HEPLIPASE. DR PRINTS; PR00821; TAGLIPASE. DR SMART; SM00308; LH2; 1. DR SUPFAM; SSF49723; SSF49723; 1. DR SUPFAM; SSF53474; SSF53474; 1. DR PROSITE; PS50095; PLAT; 1. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2}; KW Proteomics identification {ECO:0000213|MaxQB:E7EUJ1, KW ECO:0000213|PeptideAtlas:E7EUJ1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Secreted {ECO:0000256|SAAS:SAAS00439306}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 499 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003219506. FT DOMAIN 352 493 PLAT. {ECO:0000259|PROSITE:PS50095}. FT ACT_SITE 168 168 Nucleophile. FT {ECO:0000256|PIRSR:PIRSR000865-1}. FT ACT_SITE 194 194 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR000865-1}. FT ACT_SITE 279 279 Charge relay system. FT {ECO:0000256|PIRSR:PIRSR000865-1}. FT METAL 208 208 Calcium; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000865-2}. FT METAL 213 213 Calcium. {ECO:0000256|PIRSR:PIRSR000865- FT 2}. SQ SEQUENCE 499 AA; 55617 MW; C5FED21BD5574072 CRC64; MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK VYHYQFKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL KTIRVKAGET QQRSPNRINL GRLNCSLLFC TELFSHDSLA HWSSAASEL //