ID   E7ETN9_HUMAN            Unreviewed;       180 AA.
AC   E7ETN9;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   05-DEC-2018, entry version 53.
DE   SubName: Full=Uroplakin-1b {ECO:0000313|Ensembl:ENSP00000418972};
GN   Name=UPK1B {ECO:0000313|Ensembl:ENSP00000418972};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000418972, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000418972, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000418972}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|SAAS:SAAS00562291}.
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DR   EMBL; AC083800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ETN9; -.
DR   MaxQB; E7ETN9; -.
DR   PRIDE; E7ETN9; -.
DR   Ensembl; ENST00000497685; ENSP00000418972; ENSG00000114638.
DR   UCSC; uc011bix.3; human.
DR   EuPathDB; HostDB:ENSG00000114638.7; -.
DR   HGNC; HGNC:12578; UPK1B.
DR   OpenTargets; ENSG00000114638; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000160779; -.
DR   ChiTaRS; UPK1B; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000114638; Expressed in 109 organ(s), highest expression level in palpebral conjunctiva.
DR   ExpressionAtlas; E7ETN9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   InterPro; IPR034766; Uroplakin-1b.
DR   PANTHER; PTHR19282:SF24; PTHR19282:SF24; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00066888, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E7ETN9,
KW   ECO:0000213|PeptideAtlas:E7ETN9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00066888,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00066888,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    180       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219312.
FT   TRANSMEM    153    175       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   180 AA;  21097 MW;  FFA9A2E1A4EC0D54 CRC64;
     MKSSRKILLA YFILMFIVYA FEVASCITAA TQQDFFTPNL FLKQMLERYQ NNSPPNNDDQ
     WKNNGVTKTW DRLMLQDNCC GVNGPSDWQK YTSAFRTENN DADYPWPRQC CVMNNLKEPL
     NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI LCWTFWVLLG TMFYWSRIEY
//