ID   E7ETN3_HUMAN            Unreviewed;      1115 AA.
AC   E7ETN3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000418996};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000418996, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000418996, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000418996}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AL645922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ETN3; -.
DR   BioMuta; ENSG00000244255; -.
DR   jPOST; E7ETN3; -.
DR   MaxQB; E7ETN3; -.
DR   PeptideAtlas; E7ETN3; -.
DR   PRIDE; E7ETN3; -.
DR   Ensembl; ENST00000477310; ENSP00000418996; ENSG00000244255.
DR   UCSC; uc063nji.1; human.
DR   EuPathDB; HostDB:ENSG00000244255.5; -.
DR   GeneCards; ENSG00000244255; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000158605; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000244255; Expressed in 67 organ(s), highest expression level in liver.
DR   ExpressionAtlas; E7ETN3; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00033; CCP; 3.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 3.40.50.410; -; 2.
DR   InterPro; IPR028341; Complement_B.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR19325:SF394; PTHR19325:SF394; 3.
DR   Pfam; PF00084; Sushi; 3.
DR   Pfam; PF00089; Trypsin; 2.
DR   Pfam; PF00092; VWA; 2.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00032; CCP; 4.
DR   SMART; SM00020; Tryp_SPc; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF50494; SSF50494; 2.
DR   SUPFAM; SSF53300; SSF53300; 2.
DR   SUPFAM; SSF57535; SSF57535; 4.
DR   PROSITE; PS50923; SUSHI; 4.
DR   PROSITE; PS50240; TRYPSIN_DOM; 2.
DR   PROSITE; PS00134; TRYPSIN_HIS; 2.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7ETN3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1115       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219491.
FT   DOMAIN       22     86       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN       87    146       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      235    691       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   DOMAIN      452    511       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      514    571       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      621    820       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      828   1108       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   DISULFID    117    144       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    482    509       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    542    569       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   1115 AA;  124017 MW;  C98F353FDB37F25B CRC64;
     MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS CPQGLYPSPA
     SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY TPRLGSYPVG GNVSFECEDG
     FILRGSPVRQ CRPNGMWDGE TAVCDNGDHE NGTGTNTYAA LNSVYLMMNN QMRLLGMETM
     AWQEIRHAII LLTDGKSNMG GSPKTAVDHI REILNINQKR NDYLDVSKLT DTICGVGNMS
     ANASDQERTP WHVTIKPKSQ ETCRGALISD QWVLTAAHCF RDGNDHSLWR VNVGDPKSQW
     GKEFLIEKAV ISPGFDVFAK KNQGILEFYG DDIALLKLAQ KVKMSTHARP ICLPCTMEAN
     LALRRPQGST CRDHENELLN KQSVPAHFVA LNGSKLNINL KMGVEWTSCA EVVSQEKTMF
     PNLTDVREVV TDQFLCSGTQ EDESPCKGGS AIHCPRPHDF ENGEYWPRSP YYNVSDEISF
     HCYDGYTLRG SANRTCQVNG RWSGQTAICD NGAGYCSNPG IPIGTRKVGS QYRLEDSVTY
     HCSRGLTLRG SQRRTCQEGG SWSGTEPSCQ DSFMYDTPQE VAEAFLSSLT ETIEGVDAED
     GHGPGEQQKR KIVLDPSGSM NIYLVLDGSD SIGASNFTGA KKCLVNLIEK VASYGVKPRY
     GLVTYATYPK IWVKVSEADS SNADWVTKQL NEINYEDHKL KSGTNTKKAL QAVYSMMSWP
     DDVPPEGWNR TRHVIILMTD GLHNMGGDPI TVIDEIRDLL YIGKDRKNPR EDYLDVYVFG
     VGPLVNQVNI NALASKKDNE QHVFKVKDME NLEDVFYQMI DESQSLSLCG MVWEHRKGTD
     YHKQPWQAKI SVIRPSKGHE SCMGAVVSEY FVLTAAHCFT VDDKEHSIKV SVGGEKRDLE
     IEVVLFHPNY NINGKKEAGI PEFYDYDVAL IKLKNKLKYG QTIRPICLPC TEGTTRALRL
     PPTTTCQQQK EELLPAQDIK ALFVSEEEKK LTRKEVYIKN GDKKGSCERD AQYAPGYDKV
     KDISEVVTPR FLCTGGVSPY ADPNTCRGDS GGPLIVHKRS RFIQVGVISW GVVDVCKNQK
     RQKQVPAHAR DFHINLFQVL PWLKEKLQDE DLGFL
//