ID   E7ETG2_HUMAN            Unreviewed;       874 AA.
AC   E7ETG2;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=Serine/threonine-protein kinase/endoribonuclease IRE2 {ECO:0000313|Ensembl:ENSP00000413812};
GN   Name=ERN2 {ECO:0000313|Ensembl:ENSP00000413812};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413812, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000413812, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000413812}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001295149.2; NM_001308220.1.
DR   UniGene; Hs.592041; -.
DR   ProteinModelPortal; E7ETG2; -.
DR   jPOST; E7ETG2; -.
DR   PeptideAtlas; E7ETG2; -.
DR   PRIDE; E7ETG2; -.
DR   Ensembl; ENST00000457008; ENSP00000413812; ENSG00000134398.
DR   GeneID; 10595; -.
DR   UCSC; uc059sdy.1; human.
DR   CTD; 10595; -.
DR   EuPathDB; HostDB:ENSG00000134398.13; -.
DR   HGNC; HGNC:16942; ERN2.
DR   OpenTargets; ENSG00000134398; -.
DR   GeneTree; ENSGT00940000160812; -.
DR   OrthoDB; 1019877at2759; -.
DR   SignaLink; E7ETG2; -.
DR   ChiTaRS; ERN2; human.
DR   GenomeRNAi; 10595; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000134398; Expressed in 210 organ(s), highest expression level in nasal cavity epithelium.
DR   ExpressionAtlas; E7ETG2; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   Gene3D; 1.20.1440.180; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033523; IRE2.
DR   InterPro; IPR010513; KEN_dom.
DR   InterPro; IPR038357; KEN_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR018997; PUB_domain.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR13954:SF15; PTHR13954:SF15; 2.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF06479; Ribonuc_2-5A; 1.
DR   SMART; SM00564; PQQ; 4.
DR   SMART; SM00580; PUG; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51392; KEN; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7ETG2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     34       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        35    874       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217532.
FT   DOMAIN      468    729       Protein kinase.
FT                                {ECO:0000259|PROSITE:PS50011}.
FT   DOMAIN      732    860       KEN. {ECO:0000259|PROSITE:PS51392}.
SQ   SEQUENCE   874 AA;  96689 MW;  C935735502EEBE7E CRC64;
     MASAVRGSRP WPRLGLQLQF AALLLGTLSP QVHTLRPENL LLVSTLDGSL HALSKQTGDL
     KWTLRDDPVI EGPMYVTEMA FLSDPADGSL YILGTQKQQG LMKLPFTIPE LVHASPCRSS
     DGVFYTGRKQ DAWFVVDPES GETQMTLTTE GPSTPRLYIG RTQYTVTMHD PRAPALRWNT
     TYRRYSAPPM DGSPGKYMSH LASCGMGLLL TVDPGSGTVL WTQDLGVPVM GVYTWHQDGL
     RQLPHLTLAR DTLHFLALRW GHIRLPASGP RDTATLFSTL DTQLLMTLYV GKDETGFYVS
     KALVHTGVAL VPRGLTLAPA DGPTTDEVTL QVSGEREGSP STAVRYPSGS VALPSQWLLI
     GHHELPPVLH TTMLRVHPTL GSGTAETRPP ENTQAPAFFL EQQPQVVEKQ QETPLAPADF
     AHISQDAQSL HSGASRRSQK RLQSPSKQAQ PLDDPEAEQL TVVGKISFNP KDVLGRGAGG
     TFVFRGQFEG RAVAVKRLLR ECFGLVRREV QLLQESDRHP NVLRYFCTER GPQFHYIALE
     LCRASLQEYV ENPDLDRGGL EPEVVLQQLM SGLAHLHSLH IVHRDLKPGN ILITGPDSQG
     LGRVVLSDFG LCKKLPAGRC SFSLHSGIPG TEGWMAPELL QLLPPDSPTS AVDIFSAGCV
     FYYVLSGGSH PFGDSLYRQA NILTGAPCLA HLEEEVHDKV VARDLVGAML SPLPQPRPSA
     PQVLAHPFFW SRAKQLQFFQ DVSDWLEKES EQEPLVRALE AGGCAVVRDN WHEHISMPLQ
     TDLRKFRSYK GTSVRDLLRA VRNKKHHYRE LPVEVRQALG QVPDGFVQYF TNRFPRLLLH
     THRAMRSCAS ESLFLPYYPP DSEARRPCPG ATGR
//