ID   E7ESX1_HUMAN            Unreviewed;       954 AA.
AC   E7ESX1;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 51.
DE   RecName: Full=Chordin {ECO:0000256|PIRNR:PIRNR002496};
GN   Name=CHRD {ECO:0000313|Ensembl:ENSP00000408972};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408972, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408972, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000408972}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Dorsalizing factor. Key developmental protein that
CC       dorsalizes early vertebrate embryonic tissues by binding to
CC       ventralizing TGF-beta family bone morphogenetic proteins (BMPs)
CC       and sequestering them in latent complexes.
CC       {ECO:0000256|PIRNR:PIRNR002496}.
CC   -!- SIMILARITY: Belongs to the chordin family.
CC       {ECO:0000256|PIRNR:PIRNR002496}.
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DR   EMBL; AC078797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001291401.1; NM_001304472.1.
DR   UniGene; Hs.166186; -.
DR   ProteinModelPortal; E7ESX1; -.
DR   jPOST; E7ESX1; -.
DR   PeptideAtlas; E7ESX1; -.
DR   PRIDE; E7ESX1; -.
DR   Ensembl; ENST00000450923; ENSP00000408972; ENSG00000090539.
DR   GeneID; 8646; -.
DR   UCSC; uc003fox.4; human.
DR   CTD; 8646; -.
DR   EuPathDB; HostDB:ENSG00000090539.15; -.
DR   HGNC; HGNC:1949; CHRD.
DR   OpenTargets; ENSG00000090539; -.
DR   eggNOG; ENOG410IEDE; Eukaryota.
DR   eggNOG; ENOG410XSBA; LUCA.
DR   GeneTree; ENSGT00940000161767; -.
DR   OrthoDB; 647180at2759; -.
DR   ChiTaRS; CHRD; human.
DR   GenomeRNAi; 8646; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000090539; Expressed in 144 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; E7ESX1; baseline and differential.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-UniRule.
DR   InterPro; IPR016353; Chordin.
DR   InterPro; IPR010895; CHRD.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF07452; CHRD; 2.
DR   Pfam; PF00093; VWC; 3.
DR   PIRSF; PIRSF002496; Chordin; 1.
DR   SMART; SM00754; CHRD; 4.
DR   SMART; SM00214; VWC; 4.
DR   PROSITE; PS50933; CHRD; 4.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Developmental protein {ECO:0000256|PIRNR:PIRNR002496,
KW   ECO:0000256|PROSITE-ProRule:PRU00230};
KW   Proteomics identification {ECO:0000213|MaxQB:E7ESX1,
KW   ECO:0000213|PeptideAtlas:E7ESX1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    954       Chordin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217525.
FT   DOMAIN       49    126       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      168    277       CHRD. {ECO:0000259|PROSITE:PS50933}.
FT   DOMAIN      279    402       CHRD. {ECO:0000259|PROSITE:PS50933}.
FT   DOMAIN      403    524       CHRD. {ECO:0000259|PROSITE:PS50933}.
FT   DOMAIN      530    650       CHRD. {ECO:0000259|PROSITE:PS50933}.
FT   DOMAIN      703    763       VWFC. {ECO:0000259|PROSITE:PS50184}.
SQ   SEQUENCE   954 AA;  101961 MW;  557AC50B00D5AF14 CRC64;
     MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG CTFGGKVYAL
     DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK NIKPECPTPA CGQPRQLPGH
     CCQTCPQERS SSERQPSGLS FEYPRDPEHR SYSDRGEPGA EERARGDGHT DFVALLTGPR
     SQAVARARVS LLRSSLRFSI SYRRLDRPTR IRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA
     VPRLSLRLLR AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI
     TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA NVSAQEPGFA
     EVLPNLTVQE MDWLVLGELQ MALEWAGRPG LRISGHIAAR KSCDVLQSVL CGADALIPVQ
     TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT
     AVGICPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG
     ALVLPPVKSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK
     GFYGSEAQGV VKDLEPELLR HLAKGMASLM ITTKGSPRGE LRGQVHIANQ CEVGGLRLEA
     AGAEGVRALG APDTASAAPP VVPGLPALAP AKPGGPGRPR DPNTCFFEGQ QRPHGARWAP
     NYDPLCSLCT CQRRTVICDP VVCPPPSCPH PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP
     GEGCYFDGDR SWRAAGTRWH PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR
     VNPTDCCKQC PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC
     RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPPE TRTDPELEKE AEGS
//