ID   E7ESP4_HUMAN            Unreviewed;       942 AA.
AC   E7ESP4;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   13-FEB-2019, entry version 64.
DE   SubName: Full=Integrin alpha-2 {ECO:0000313|Ensembl:ENSP00000422145};
GN   Name=ITGA2 {ECO:0000313|Ensembl:ENSP00000422145};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422145, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422145, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000422145}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC       {ECO:0000256|SAAS:SAAS01130326}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00534092}.
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DR   EMBL; AC008966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC876967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ESP4; -.
DR   IntAct; E7ESP4; 1.
DR   EPD; E7ESP4; -.
DR   jPOST; E7ESP4; -.
DR   MaxQB; E7ESP4; -.
DR   PeptideAtlas; E7ESP4; -.
DR   PRIDE; E7ESP4; -.
DR   Ensembl; ENST00000510722; ENSP00000422145; ENSG00000164171.
DR   UCSC; uc063dng.1; human.
DR   EuPathDB; HostDB:ENSG00000164171.10; -.
DR   HGNC; HGNC:6137; ITGA2.
DR   OpenTargets; ENSG00000164171; -.
DR   eggNOG; ENOG410IPB9; Eukaryota.
DR   eggNOG; ENOG4110534; LUCA.
DR   GeneTree; ENSGT00940000156303; -.
DR   SignaLink; E7ESP4; -.
DR   ChiTaRS; ITGA2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000164171; Expressed in 173 organ(s), highest expression level in visceral pleura.
DR   ExpressionAtlas; E7ESP4; baseline and differential.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; -; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF69179; SSF69179; 2.
DR   PROSITE; PS51470; FG_GAP; 7.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS01101218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Integrin {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494682};
KW   Membrane {ECO:0000256|SAAS:SAAS00494657};
KW   Proteomics identification {ECO:0000213|EPD:E7ESP4,
KW   ECO:0000213|MaxQB:E7ESP4, ECO:0000213|PeptideAtlas:E7ESP4};
KW   Receptor {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS01101220};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00504086};
KW   Signal {ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00494657};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00494657}.
FT   SIGNAL        1     29       {ECO:0000256|RuleBase:RU003762}.
FT   CHAIN        30    942       {ECO:0000256|RuleBase:RU003762}.
FT                                /FTId=PRO_5001424252.
FT   REPEAT       34     92       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      101    161       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   DOMAIN      174    361       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   REPEAT      366    420       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      423    475       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      477    539       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      540    598       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      602    664       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
SQ   SEQUENCE   942 AA;  102827 MW;  97ADB8ACC591A939 CRC64;
     MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG
     NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT
     RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD
     ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS
     QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN
     HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ
     IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP
     KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ
     AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKEGILGQH
     QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY
     SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ SIADVAIEAS
     FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI TLDADGFSSR VTSRGLFKEN
     NERCLQKNMV VNQAQSCPEH IIYIQEPSDV VNSLDLRVDI SLENPGTSPA LEAYSETAKV
     FSIPFHKDCG EDGLCISDLV LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG
     IVVDFSENLF FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ
     NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TR
//