ID E7ESK6_HUMAN Unreviewed; 165 AA. AC E7ESK6; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 16-JAN-2019, entry version 59. DE RecName: Full=Syndecan {ECO:0000256|RuleBase:RU000649}; GN Name=SDC2 {ECO:0000313|Ensembl:ENSP00000429045}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429045, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000429045, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., RA Blagoev B.; RT "System-wide temporal characterization of the proteome and RT phosphoproteome of human embryonic stem cell differentiation."; RL Sci. Signal. 4:rs3-RS3(2011). RN [4] {ECO:0000313|Ensembl:ENSP00000429045} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [5] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Cell surface proteoglycan. CC {ECO:0000256|RuleBase:RU000649}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000649}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU000649}. CC -!- SIMILARITY: Belongs to the syndecan proteoglycan family. CC {ECO:0000256|RuleBase:RU000649}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AP003477; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP003548; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877279; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7ESK6; -. DR IntAct; E7ESK6; 8. DR EPD; E7ESK6; -. DR jPOST; E7ESK6; -. DR MaxQB; E7ESK6; -. DR PeptideAtlas; E7ESK6; -. DR PRIDE; E7ESK6; -. DR Ensembl; ENST00000518385; ENSP00000429045; ENSG00000169439. DR UCSC; uc064ouo.1; human. DR EuPathDB; HostDB:ENSG00000169439.11; -. DR HGNC; HGNC:10659; SDC2. DR OpenTargets; ENSG00000169439; -. DR GeneTree; ENSGT00940000157222; -. DR ChiTaRS; SDC2; human. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000169439; Expressed in 231 organ(s), highest expression level in tibia. DR ExpressionAtlas; E7ESK6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR InterPro; IPR003585; Neurexin-like. DR InterPro; IPR001050; Syndecan. DR InterPro; IPR031201; Syndecan-2. DR InterPro; IPR027789; Syndecan/Neurexin_dom. DR InterPro; IPR030479; Syndecan_CS. DR PANTHER; PTHR10915; PTHR10915; 1. DR PANTHER; PTHR10915:SF6; PTHR10915:SF6; 1. DR Pfam; PF01034; Syndecan; 1. DR SMART; SM00294; 4.1m; 1. DR PROSITE; PS00964; SYNDECAN; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Glycoprotein {ECO:0000256|RuleBase:RU000649}; KW Heparan sulfate {ECO:0000256|RuleBase:RU000649}; KW Membrane {ECO:0000256|SAAS:SAAS00416869, ECO:0000256|SAM:Phobius}; KW Proteoglycan {ECO:0000256|RuleBase:RU000649}; KW Proteomics identification {ECO:0000213|EPD:E7ESK6, KW ECO:0000213|MaxQB:E7ESK6, ECO:0000213|PeptideAtlas:E7ESK6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00416869, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00416869, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 165 Syndecan. {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003217327. FT TRANSMEM 109 133 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 132 150 4.1m. {ECO:0000259|SMART:SM00294}. SQ SEQUENCE 165 AA; 18388 MW; A97B5D2129EEB26D CRC64; MRRAWILLTL GLVACVSAES VRADEDVESP ELTTSRPLPK ILLTSAAPKV ETTTLNIQNK IPAQTKSPEE TDKEKVHLSD SERKMDPAEE DTNVYTEKHS DSLFKRTEVL AAVIAGGVIG FLFAIFLILL LVYRMRKKDE GSYDLGERKP SSAAYQKAPT KEFYA //