ID   E7ESF5_HUMAN            Unreviewed;       138 AA.
AC   E7ESF5;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Calcitonin gene-related peptide 2 {ECO:0000313|Ensembl:ENSP00000428882};
GN   Name=CALCB {ECO:0000313|Ensembl:ENSP00000428882};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428882, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428882, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428882}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC090744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC103827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FO082042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ESF5; -.
DR   PRIDE; E7ESF5; -.
DR   Ensembl; ENST00000523376; ENSP00000428882; ENSG00000175868.
DR   UCSC; uc057zjf.1; human.
DR   EuPathDB; HostDB:ENSG00000175868.13; -.
DR   HGNC; HGNC:1438; CALCB.
DR   OpenTargets; ENSG00000175868; -.
DR   eggNOG; ENOG410IYZP; Eukaryota.
DR   eggNOG; ENOG410YIU3; LUCA.
DR   GeneTree; ENSGT00940000156267; -.
DR   OMA; VKDFVQM; -.
DR   PhylomeDB; E7ESF5; -.
DR   ChiTaRS; CALCB; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000175868; Expressed in 70 organ(s), highest expression level in dorsal root ganglion.
DR   ExpressionAtlas; E7ESF5; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50,
KW   ECO:0000256|SAAS:SAAS00897123};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7ESF5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     36       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        37    138       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003218995.
FT   DOMAIN       91    133       CALCITONIN. {ECO:0000259|SMART:SM00113}.
FT   DISULFID     94     99       {ECO:0000256|PIRSR:PIRSR621116-50}.
SQ   SEQUENCE   138 AA;  14919 MW;  B4F9EDD047C88443 CRC64;
     MKKEANLQRG GMGFRKFSPF LALSILVLYQ AGSLQAAPFR SALESSPDPA TLSKEDARLL
     LAALVQDYVQ MKASELKQEQ ETQGSSSAAQ KRACNTATCV THRLAGLLSR SGGMVKSNFV
     PTNVGSKAFG RRRRDLQA
//