ID   E7ESB3_HUMAN            Unreviewed;       201 AA.
AC   E7ESB3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 49.
DE   RecName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase {ECO:0000256|RuleBase:RU361228};
DE            EC=2.4.2.31 {ECO:0000256|RuleBase:RU361228};
DE   AltName: Full=Mono(ADP-ribosyl)transferase {ECO:0000256|RuleBase:RU361228};
DE   Flags: Fragment;
GN   Name=ART3 {ECO:0000313|Ensembl:ENSP00000422287};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422287, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422287, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422287}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-
CC         ribosyl)-L-arginyl-[protein] + nicotinamide;
CC         Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC         COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154,
CC         ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554;
CC         EC=2.4.2.31; Evidence={ECO:0000256|RuleBase:RU361228};
CC   -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase
CC       family. {ECO:0000256|RuleBase:RU361228}.
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DR   EMBL; AC112719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ESB3; -.
DR   jPOST; E7ESB3; -.
DR   PeptideAtlas; E7ESB3; -.
DR   PRIDE; E7ESB3; -.
DR   Ensembl; ENST00000513122; ENSP00000422287; ENSG00000156219.
DR   UCSC; uc062xkt.1; human.
DR   EuPathDB; HostDB:ENSG00000156219.16; -.
DR   HGNC; HGNC:725; ART3.
DR   OpenTargets; ENSG00000156219; -.
DR   eggNOG; ENOG410J8VA; Eukaryota.
DR   eggNOG; ENOG411167J; LUCA.
DR   GeneTree; ENSGT00940000153465; -.
DR   ChiTaRS; ART3; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000156219; Expressed in 136 organ(s), highest expression level in biceps brachii.
DR   ExpressionAtlas; E7ESB3; baseline and differential.
DR   GO; GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006471; P:protein ADP-ribosylation; IEA:InterPro.
DR   InterPro; IPR000768; ART.
DR   Pfam; PF01129; ART; 1.
DR   PRINTS; PR00970; RIBTRNSFRASE.
DR   PROSITE; PS01291; ART; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU361228};
KW   NAD {ECO:0000256|RuleBase:RU361228};
KW   NADP {ECO:0000256|RuleBase:RU361228};
KW   Proteomics identification {ECO:0000213|MaxQB:E7ESB3,
KW   ECO:0000213|PeptideAtlas:E7ESB3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU361228};
KW   Transferase {ECO:0000256|RuleBase:RU361228}.
FT   SIGNAL        1     26       {ECO:0000256|RuleBase:RU361228}.
FT   CHAIN        27    201       NAD(P)(+)--arginine ADP-
FT                                ribosyltransferase.
FT                                {ECO:0000256|RuleBase:RU361228}.
FT                                /FTId=PRO_5008192330.
FT   NON_TER     201    201       {ECO:0000313|Ensembl:ENSP00000422287}.
SQ   SEQUENCE   201 AA;  23092 MW;  8CC2B67094E25EDC CRC64;
     MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK
     ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK
     MAGQSREDYI YGFQFKAFHF YLTRALQLLR KPCEASSKTV VYRTSQGTSF TFGGLNQARF
     GHFTLAYSAK PQAANDQLTV L
//