ID   E7ES21_HUMAN            Unreviewed;       969 AA.
AC   E7ES21;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 69.
DE   SubName: Full=Hephaestin {ECO:0000313|Ensembl:ENSP00000413211};
GN   Name=HEPH {ECO:0000313|Ensembl:ENSP00000413211};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413211, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000413211, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000413211}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC       {ECO:0000256|SAAS:SAAS00534212}.
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DR   EMBL; AL030998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL157698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001269070.1; NM_001282141.1.
DR   UniGene; Hs.31720; -.
DR   ProteinModelPortal; E7ES21; -.
DR   jPOST; E7ES21; -.
DR   MaxQB; E7ES21; -.
DR   PeptideAtlas; E7ES21; -.
DR   PRIDE; E7ES21; -.
DR   Ensembl; ENST00000419594; ENSP00000413211; ENSG00000089472.
DR   GeneID; 9843; -.
DR   UCSC; uc010nkr.5; human.
DR   CTD; 9843; -.
DR   EuPathDB; HostDB:ENSG00000089472.16; -.
DR   HGNC; HGNC:4866; HEPH.
DR   OpenTargets; ENSG00000089472; -.
DR   eggNOG; KOG1263; Eukaryota.
DR   eggNOG; COG2132; LUCA.
DR   GeneTree; ENSGT00940000158517; -.
DR   OrthoDB; 454773at2759; -.
DR   GenomeRNAi; 9843; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   Bgee; ENSG00000089472; Expressed in 204 organ(s), highest expression level in colon.
DR   ExpressionAtlas; E7ES21; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro.
DR   GO; GO:0006826; P:iron ion transport; IEA:InterPro.
DR   Gene3D; 2.60.40.420; -; 4.
DR   InterPro; IPR011706; Cu-oxidase_2.
DR   InterPro; IPR011707; Cu-oxidase_3.
DR   InterPro; IPR033138; Cu_oxidase_CS.
DR   InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR027154; HEPH.
DR   PANTHER; PTHR44048:SF1; PTHR44048:SF1; 2.
DR   Pfam; PF07731; Cu-oxidase_2; 1.
DR   Pfam; PF07732; Cu-oxidase_3; 2.
DR   SUPFAM; SSF49503; SSF49503; 5.
DR   PROSITE; PS00079; MULTICOPPER_OXIDASE1; 2.
DR   PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Copper {ECO:0000256|SAAS:SAAS00524507};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00524516};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00644416};
KW   Proteomics identification {ECO:0000213|MaxQB:E7ES21,
KW   ECO:0000213|PeptideAtlas:E7ES21};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    969       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219473.
FT   TRANSMEM    918    943       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    207       Plastocyanin-like.
FT                                {ECO:0000259|Pfam:PF07732}.
FT   DOMAIN      620    680       Plastocyanin-like.
FT                                {ECO:0000259|Pfam:PF07732}.
FT   DOMAIN      767    873       Plastocyanin-like.
FT                                {ECO:0000259|Pfam:PF07731}.
SQ   SEQUENCE   969 AA;  109767 MW;  223D98D789B71CB3 CRC64;
     MWAMESGHLL WALLFMQSLW PQLTDGATRV YYLGIRDVQW NYAPKGRNVI TNQPLDSDIV
     ASSFLKSDKN RIGGTYKKTI YKEYKDDSYT DEVAQPAWLG FLGPVLQAEV GDVILIHLKN
     FATRPYTIHP HGVFYEKDSE GSLYPDGSSG PLKADDSVPP GGSHIYNWTI PEGHAPTDAD
     PACLTWIYHS HVDAPRDIAT GLIGPLITCK RGALDGNSPP QRQDVDHDFF LLFSVVDENL
     SWHLNENIAT YCSDPASVDK EDETFQESNR MHAINGFVFG NLPELNMCAQ KRVAWHLFGM
     GNEIDVHTAF FHGQMLTTRG HHTDVANIFP ATFVTAEMVP WEPGTWLISC QVNSHFRDGM
     QALYKVKSCS MAPPVDLLTG KVRQYFIEAH EIQWDYGPMG HDGSTGKNLR EPGSISDKFF
     QKSSSRIGGT YWKVRYEAFQ DETFQEKMHL EEDRHLGILG PVIRAEVGDT IQVVFYNRAS
     QPFSMQPHGV FYEKDYEGTV YNDGTFEIYC QAGSHREAGM RAIYNVSQCP GHQATPRQRY
     QAARIYYIMA EEVEWDYCPD RSWEREWHNQ SEKDSYGYIF LSNKDGLLGS RYKKAVFREY
     TDGTFRIPRP RTGPEEHLGI LGPLIKGEVG DILTVVFKNN ASRPYSVHAH GVLESTTVWP
     LAAEPGEVVT YQWNIPERSG PGPNDSACVS WIYYSAVDPI KDMYSGLVGP LAICQKGILE
     PHGGRSDMDR EFALLFLIFD ENKSWYLEEN VATHGSQDPG SINLQDETFL ESNKMHAING
     KLYANLRGLT MYQGERVAWY MLAMGQDVDL HTIHFHAESF LYRNGENYRA DVVDLFPGTF
     EVVEMVASNP GTWLMHCHVT DHVHAGMETL FTVFSRTEHL SPLTVITKET EKAVPPRDIE
     EGNVKMLGMQ IPIKNVEMLA SVLVAISVTL LLVVLALGGV VWYQHRQRKL RRNRRSILDD
     SFKLLSFKQ
//