ID   E7ERY4_HUMAN            Unreviewed;       325 AA.
AC   E7ERY4;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   05-DEC-2018, entry version 53.
DE   SubName: Full=Interleukin-5 receptor subunit alpha {ECO:0000313|Ensembl:ENSP00000388858};
GN   Name=IL5RA {ECO:0000313|Ensembl:ENSP00000388858};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000388858, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000388858, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000388858}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC022002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ERY4; -.
DR   MaxQB; E7ERY4; -.
DR   PeptideAtlas; E7ERY4; -.
DR   PRIDE; E7ERY4; -.
DR   Ensembl; ENST00000418488; ENSP00000388858; ENSG00000091181.
DR   UCSC; uc062gca.1; human.
DR   EuPathDB; HostDB:ENSG00000091181.19; -.
DR   HGNC; HGNC:6017; IL5RA.
DR   OpenTargets; ENSG00000091181; -.
DR   eggNOG; ENOG410IJ36; Eukaryota.
DR   eggNOG; ENOG4111ZG2; LUCA.
DR   GeneTree; ENSGT00940000160890; -.
DR   ChiTaRS; IL5RA; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000091181; Expressed in 85 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; E7ERY4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR   InterPro; IPR015321; TypeI_recpt_CBD.
DR   Pfam; PF09240; IL6Ra-bind; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7ERY4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    325       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217510.
FT   TRANSMEM    247    267       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      131    236       IL6Ra-bind. {ECO:0000259|Pfam:PF09240}.
SQ   SEQUENCE   325 AA;  36772 MW;  EE110E1CFD75E3D2 CRC64;
     MIIVAHVLLI LLGATEILQA DLLPDEKISL LPPVNFTIKV TGLAQVLLQW KPNPDQEQRN
     VNLEYQVKIN APKEDDYETR ITESKCVTIL HKGFSASVRT ILQNDHSLLA SSWASAELHA
     PPGSPGTSIV NLTCTTNTTE DNYSRLRSYQ VSLHCTWLVG TDAPEDTQYF LYYRYGSWTE
     ECQEYSKDTL GRNIACWFPR TFILSKGRDW LAVLVNGSSK HSAIRPFDQL FALHAIGNDE
     HKPLREWFVI VIMATICFIL LILSLICKIC HLWIKLFPPI PAPKSNIKDL FVTTNYEKAG
     SSETEIEVIC YIEKPGVETL EDSVF
//