ID   E7ERL8_HUMAN            Unreviewed;      1507 AA.
AC   E7ERL8;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=Neurexin-1-beta {ECO:0000313|Ensembl:ENSP00000385017};
GN   Name=NRXN1 {ECO:0000313|Ensembl:ENSP00000385017};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385017, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000385017, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000385017}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AC007462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC078994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001317007.1; NM_001330078.1.
DR   UniGene; Hs.637685; -.
DR   ProteinModelPortal; E7ERL8; -.
DR   MaxQB; E7ERL8; -.
DR   PRIDE; E7ERL8; -.
DR   Ensembl; ENST00000401669; ENSP00000385017; ENSG00000179915.
DR   GeneID; 9378; -.
DR   UCSC; uc061jbg.1; human.
DR   CTD; 9378; -.
DR   EuPathDB; HostDB:ENSG00000179915.21; -.
DR   HGNC; HGNC:8008; NRXN1.
DR   OpenTargets; ENSG00000179915; -.
DR   eggNOG; KOG3514; Eukaryota.
DR   eggNOG; ENOG410XNU6; LUCA.
DR   GeneTree; ENSGT00940000154292; -.
DR   OrthoDB; 35129at2759; -.
DR   ChiTaRS; NRXN1; human.
DR   GenomeRNAi; 9378; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000179915; Expressed in 176 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; E7ERL8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR037440; Neurexin.
DR   InterPro; IPR003585; Neurexin-like.
DR   InterPro; IPR027789; Syndecan/Neurexin_dom.
DR   PANTHER; PTHR44287; PTHR44287; 2.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF02210; Laminin_G_2; 6.
DR   Pfam; PF01034; Syndecan; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00282; LamG; 6.
DR   SUPFAM; SSF49899; SSF49899; 6.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00814887};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS00094946, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7ERL8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00094946,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00094946,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   1507       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219291.
FT   TRANSMEM   1433   1453       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    217       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      219    256       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      283    473       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      480    672       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      676    713       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      718    891       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      905   1080       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN     1083   1120       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1126   1324       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
SQ   SEQUENCE   1507 AA;  165446 MW;  D1716CC37589747E CRC64;
     MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT
     RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR
     RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF
     KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ
     AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP
     IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG
     KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP
     STADLPGSPV SNNFMGCLKE VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD
     PITFETPESF ISLPKWNAKK TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF
     FAIEMLDGHL YLLLDMGSGT IKIKALLKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA
     PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA
     EVQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS
     YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV
     NLDCIRINCN SSKGPETLFA GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT
     RLEFHNIETG IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR
     NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG
     YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL
     DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC
     EGPSTTCQED SCSNQGVCLQ QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP
     PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI
     EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG NNDNERLAIA RQRIPYRLGR
     VVDEWLLDKG RQLTIFNSQA TIIIGGKEQG QPFQGQLSGL YYNGLKVLNM AAENDANIAI
     VGNVRLVGEV PSSMTTESTA TAMQSEMSTS IMETTTTLAT STARRGKPPT KEPISQTTDD
     ILVASAECPS DDEDIDPCEP SSGGLANPTR AGGREPYPGS AEVIRESSST TGMVVGIVAA
     AALCILILLY AMYKYRNRDE GSYHVDESRN YISNSAQSNG AVVKEKQPSS AKSSNKNKKN
     KDKEYYV
//