ID   E7ERK3_HUMAN            Unreviewed;       309 AA.
AC   E7ERK3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-1 {ECO:0000313|Ensembl:ENSP00000405395};
GN   Name=CACNA2D1 {ECO:0000313|Ensembl:ENSP00000405395};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000405395, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000405395, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000405395}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC004892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001289819.1; NM_001302890.1.
DR   UniGene; Hs.282151; -.
DR   UniGene; Hs.592625; -.
DR   UniGene; Hs.743228; -.
DR   ProteinModelPortal; E7ERK3; -.
DR   SMR; E7ERK3; -.
DR   jPOST; E7ERK3; -.
DR   MaxQB; E7ERK3; -.
DR   PeptideAtlas; E7ERK3; -.
DR   PRIDE; E7ERK3; -.
DR   Ensembl; ENST00000423588; ENSP00000405395; ENSG00000153956.
DR   GeneID; 781; -.
DR   UCSC; uc064ewx.1; human.
DR   CTD; 781; -.
DR   EuPathDB; HostDB:ENSG00000153956.15; -.
DR   HGNC; HGNC:1399; CACNA2D1.
DR   OpenTargets; ENSG00000153956; -.
DR   eggNOG; KOG2353; Eukaryota.
DR   eggNOG; ENOG410XPDX; LUCA.
DR   GeneTree; ENSGT00940000155209; -.
DR   OrthoDB; 510149at2759; -.
DR   ChiTaRS; CACNA2D1; human.
DR   GenomeRNAi; 781; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000153956; Expressed in 204 organ(s), highest expression level in biceps brachii.
DR   ExpressionAtlas; E7ERK3; baseline and differential.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF08399; VWA_N; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E7ERK3,
KW   ECO:0000213|MaxQB:E7ERK3, ECO:0000213|PeptideAtlas:E7ERK3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    309       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219288.
FT   DOMAIN      104    223       VWA_N. {ECO:0000259|Pfam:PF08399}.
SQ   SEQUENCE   309 AA;  34621 MW;  7A3D8ADCAA481D7C CRC64;
     MAAGCLLALT LTLFQSLLIG PSSEEPFPSA VTIKSWVDKM QEDLVTLAKT ASGVNQLVDI
     YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL ALEAEKVQAA HQWREDFASN
     EVVYYNAKDD LDPEKNDSEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL
     NELNWTSALD EVFKKNREED PSLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR
     RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASDSKEISP
     SPEEIFNAE
//