ID   E7ERI1_HUMAN            Unreviewed;       184 AA.
AC   E7ERI1;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Prolyl 4-hydroxylase subunit alpha-2 {ECO:0000313|Ensembl:ENSP00000405406};
DE   Flags: Fragment;
GN   Name=P4HA2 {ECO:0000313|Ensembl:ENSP00000405406};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000405406, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000405406, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000405406}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC034220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC063976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ERI1; -.
DR   SMR; E7ERI1; -.
DR   jPOST; E7ERI1; -.
DR   MaxQB; E7ERI1; -.
DR   PeptideAtlas; E7ERI1; -.
DR   PRIDE; E7ERI1; -.
DR   Ensembl; ENST00000439698; ENSP00000405406; ENSG00000072682.
DR   UCSC; uc063gtq.1; human.
DR   EuPathDB; HostDB:ENSG00000072682.18; -.
DR   HGNC; HGNC:8547; P4HA2.
DR   OpenTargets; ENSG00000072682; -.
DR   eggNOG; KOG1591; Eukaryota.
DR   eggNOG; ENOG410XS5J; LUCA.
DR   GeneTree; ENSGT00940000157695; -.
DR   ChiTaRS; P4HA2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000072682; Expressed in 211 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; E7ERI1; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR013547; Pro_4_hyd_alph_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF08336; P4Ha_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E7ERI1,
KW   ECO:0000213|MaxQB:E7ERI1, ECO:0000213|PeptideAtlas:E7ERI1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    184       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219286.
FT   DOMAIN       26    156       P4Ha_N. {ECO:0000259|Pfam:PF08336}.
FT   NON_TER     184    184       {ECO:0000313|Ensembl:ENSP00000405406}.
SQ   SEQUENCE   184 AA;  20620 MW;  D78EAA782A29DDF0 CRC64;
     MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS
     WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR
     QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRGELPGTKY QAMLSVDDCF GMGRSAYNEG
     DYYH
//