ID E7ERG8_HUMAN Unreviewed; 781 AA. AC E7ERG8; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 16-JAN-2019, entry version 62. DE SubName: Full=Low-density lipoprotein receptor-related protein 1B {ECO:0000313|Ensembl:ENSP00000413239}; DE Flags: Fragment; GN Name=LRP1B {ECO:0000313|Ensembl:ENSP00000413239}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413239, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000413239, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000413239} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010740; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC068195; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC068287; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC073319; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC079585; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092156; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC093039; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC108036; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC110087; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC117947; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7ERG8; -. DR jPOST; E7ERG8; -. DR PeptideAtlas; E7ERG8; -. DR PRIDE; E7ERG8; -. DR Ensembl; ENST00000434794; ENSP00000413239; ENSG00000168702. DR UCSC; uc061odt.1; human. DR EuPathDB; HostDB:ENSG00000168702.16; -. DR HGNC; HGNC:6693; LRP1B. DR OpenTargets; ENSG00000168702; -. DR eggNOG; KOG1215; Eukaryota. DR eggNOG; ENOG410XP34; LUCA. DR GeneTree; ENSGT00940000157521; -. DR ChiTaRS; LRP1B; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000168702; Expressed in 133 organ(s), highest expression level in corpus callosum. DR ExpressionAtlas; E7ERG8; baseline and differential. DR CDD; cd00112; LDLa; 5. DR Gene3D; 2.120.10.30; -; 2. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF00057; Ldl_recept_a; 7. DR Pfam; PF00058; Ldl_recept_b; 3. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00181; EGF; 4. DR SMART; SM00192; LDLa; 7. DR SMART; SM00135; LY; 6. DR SUPFAM; SSF57184; SSF57184; 1. DR SUPFAM; SSF57424; SSF57424; 7. DR PROSITE; PS01209; LDLRA_1; 4. DR PROSITE; PS50068; LDLRA_2; 7. DR PROSITE; PS51120; LDLRB; 6. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124, KW ECO:0000256|SAAS:SAAS00895822}; KW EGF-like domain {ECO:0000256|SAAS:SAAS00063520}; KW Proteomics identification {ECO:0000213|PeptideAtlas:E7ERG8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00663218}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 781 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008413856. FT DOMAIN 31 73 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 320 358 EGF-like. {ECO:0000259|SMART:SM00181}. FT DOMAIN 362 398 EGF-like. {ECO:0000259|SMART:SM00181}. FT REPEAT 445 491 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 492 534 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 535 581 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 582 626 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 627 667 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DOMAIN 675 715 EGF-like. {ECO:0000259|SMART:SM00181}. FT REPEAT 763 781 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DISULFID 72 84 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 79 97 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 120 138 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 132 147 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 151 163 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 158 176 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 218 233 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 261 276 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT NON_TER 781 781 {ECO:0000313|Ensembl:ENSP00000413239}. SQ SEQUENCE 781 AA; 87157 MW; 44AA6A27DEE672BA CRC64; MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD DSDESLDTSR TCQVDQFSCG NGRCIPRAWL CDREDDCGDQ TDEMASCEFP TCEPLTQFVC KSGRCISSKW HCDSDDDCGD GSDEVGCVHS CFDNQFRCSS GRCIPGHWAC DGDNDCGDFS DEAQINCTKE EIHSPAGCNG NEFQCHPDGN CVPDLWRCDG EKDCEDGSDE KGCNGTIRLC DHKTKFSCWS TGRCINKAWV CDGDIDCEDQ SDEDDCDSFL CGPPKHPCAN DTSVCLQPEK LCNGKKDCPD GSDEGYLCDE CSLNNGGCSN HCSVVPGRGI VCSCPEGLQL NKDNKTCEIV DYCSNHLKCS QVCEQHKHTV KCSCYEGWKL DVDGESCTSV DPFEAFIIFS IRHEIRRIDL HKRDYSLLVP GLRNTIALDF HFNQSLLYWT DVVEDRIYRG KLSESGGVSA IEVVVEHGLA TPEGLTVDWI AGNIYWIDSN LDQIEVAKLD GSLRTTLIAG AMEHPRAIAL DPRYGILFWT DWDANFPRIE SASMSGAGRK TIYKDMKTGA WPNGLTVDHF EKRIVWTDAR SDAIYSALYD GTNMIEIIRG HEYLSHPFAV SLYGSEVYWT DWRTNTLSKA NKWTGQNVSV IQKTSAQPFD LQIYHPSRQP QAPNPCAAND GKGPCSHMCL INHNRSAACA CPHLMKLSSD KKTCYEMKKF LLYARRSEIR GVDIDNPYFN FITAFTVPDI DDVTVIDFDA SEERLYWTDI KTQTIKRAFI N //