ID   E7ER44_HUMAN            Unreviewed;       708 AA.
AC   E7ER44;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Lactotransferrin {ECO:0000313|Ensembl:ENSP00000405546};
GN   Name=LTF {ECO:0000313|Ensembl:ENSP00000405546};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000405546, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000405546, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000405546}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the transferrin family.
CC       {ECO:0000256|PIRNR:PIRNR002549}.
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DR   EMBL; AC098613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001308050.1; NM_001321121.1.
DR   UniGene; Hs.529517; -.
DR   ProteinModelPortal; E7ER44; -.
DR   jPOST; E7ER44; -.
DR   MaxQB; E7ER44; -.
DR   PeptideAtlas; E7ER44; -.
DR   PRIDE; E7ER44; -.
DR   Ensembl; ENST00000417439; ENSP00000405546; ENSG00000012223.
DR   GeneID; 4057; -.
DR   UCSC; uc010hjh.5; human.
DR   CTD; 4057; -.
DR   EuPathDB; HostDB:ENSG00000012223.12; -.
DR   HGNC; HGNC:6720; LTF.
DR   OpenTargets; ENSG00000012223; -.
DR   eggNOG; ENOG410IEAI; Eukaryota.
DR   eggNOG; ENOG410XQ36; LUCA.
DR   GeneTree; ENSGT00940000156055; -.
DR   OrthoDB; 232859at2759; -.
DR   ChiTaRS; LTF; human.
DR   GenomeRNAi; 4057; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000012223; Expressed in 159 organ(s), highest expression level in trachea.
DR   ExpressionAtlas; E7ER44; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:InterPro.
DR   GO; GO:0001817; P:regulation of cytokine production; IEA:InterPro.
DR   InterPro; IPR030684; Lactotransferrin.
DR   InterPro; IPR016357; Transferrin.
DR   InterPro; IPR001156; Transferrin-like_dom.
DR   InterPro; IPR018195; Transferrin_Fe_BS.
DR   PANTHER; PTHR11485:SF33; PTHR11485:SF33; 1.
DR   Pfam; PF00405; Transferrin; 2.
DR   PIRSF; PIRSF500683; Lactotransferrin; 1.
DR   PIRSF; PIRSF002549; Transferrin; 1.
DR   PRINTS; PR00422; TRANSFERRIN.
DR   SMART; SM00094; TR_FER; 2.
DR   PROSITE; PS00205; TRANSFERRIN_LIKE_1; 2.
DR   PROSITE; PS00206; TRANSFERRIN_LIKE_2; 2.
DR   PROSITE; PS00207; TRANSFERRIN_LIKE_3; 2.
DR   PROSITE; PS51408; TRANSFERRIN_LIKE_4; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E7ER44,
KW   ECO:0000213|MaxQB:E7ER44, ECO:0000213|PeptideAtlas:E7ER44};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    708       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217500.
FT   DOMAIN       25    352       Transferrin-like.
FT                                {ECO:0000259|PROSITE:PS51408}.
FT   DOMAIN      364    693       Transferrin-like.
FT                                {ECO:0000259|PROSITE:PS51408}.
FT   ACT_SITE     92     92       {ECO:0000256|PIRSR:PIRSR002549-1}.
FT   ACT_SITE    278    278       Nucleophile.
FT                                {ECO:0000256|PIRSR:PIRSR002549-1}.
SQ   SEQUENCE   708 AA;  77970 MW;  0D4702D85E1F553E CRC64;
     MKLVFLVLLF LGALGLCLAG RRRSVQWCAV SQPEATKCFQ WQRNMRKVRG PPVSCIKRDS
     PIQCIQAIAE NRADAVTLDG GFIYEAGLAP YKLRPVAAEV YGTERQPRTH YYAVAVVKKG
     GSFQLNELQG LKSCHTGLRR TAGWNVPIGT LRPFLNWTGP PEPIEAAVAR FFSASCVPGA
     DKGQFPNLCR LCAGTGENKC AFSSQEPYFS YSGAFKCLRD GAGDVAFIRE STVFEDLSDE
     AERDEYELLC PDNTRKPVDK FKDCHLARVP SHAVVARSVN GKEDAIWNLL RQAQEKFGKD
     KSPKFQLFGS PSGQKDLLFK DSAIGFSRVP PRIDSGLYLG SGYFTAIQNL RKSEEEVAAR
     RARVVWCAVG EQELRKCNQW SGLSEGSVTC SSASTTEDCI ALKGEADAMS LDGGYVYTAG
     KCGLVPVLAE NYKSQQSSDP DPNCVDRPVE GYLAVAVVRR SDTSLTWNSV KGKKSCHTAV
     DRTAGWNIPM GLLFNQTGSC KFDEYFSQSC APGSDPRSNL CALCIGDEQG ENKCVPNSNE
     RYYGYTGAFR CLAENAGDVA FVKDVTVLQN TDGNNNEAWA KDLKLADFAL LCLDGKRKPV
     TEARSCHLAM APNHAVVSRM DKVERLKQVL LHQQAKFGRN GSDCPDKFCL FQSETKNLLF
     NDNTECLARL HGKTTYEKYL GPQYVAGITN LKKCSTSPLL EACEFLRK
//