ID   E7ER42_HUMAN            Unreviewed;       174 AA.
AC   E7ER42;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 48.
DE   RecName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase {ECO:0000256|RuleBase:RU361228};
DE            EC=2.4.2.31 {ECO:0000256|RuleBase:RU361228};
DE   AltName: Full=Mono(ADP-ribosyl)transferase {ECO:0000256|RuleBase:RU361228};
DE   Flags: Fragment;
GN   Name=ART3 {ECO:0000313|Ensembl:ENSP00000425327};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425327, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425327, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000425327}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-
CC         ribosyl)-L-arginyl-[protein] + nicotinamide;
CC         Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC         COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154,
CC         ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554;
CC         EC=2.4.2.31; Evidence={ECO:0000256|RuleBase:RU361228};
CC   -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase
CC       family. {ECO:0000256|RuleBase:RU361228}.
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DR   EMBL; AC112719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ER42; -.
DR   jPOST; E7ER42; -.
DR   PeptideAtlas; E7ER42; -.
DR   PRIDE; E7ER42; -.
DR   Ensembl; ENST00000510423; ENSP00000425327; ENSG00000156219.
DR   UCSC; uc062xkx.1; human.
DR   EuPathDB; HostDB:ENSG00000156219.16; -.
DR   HGNC; HGNC:725; ART3.
DR   OpenTargets; ENSG00000156219; -.
DR   eggNOG; ENOG410J8VA; Eukaryota.
DR   eggNOG; ENOG411167J; LUCA.
DR   GeneTree; ENSGT00940000153465; -.
DR   ChiTaRS; ART3; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000156219; Expressed in 136 organ(s), highest expression level in biceps brachii.
DR   ExpressionAtlas; E7ER42; baseline and differential.
DR   GO; GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006471; P:protein ADP-ribosylation; IEA:InterPro.
DR   InterPro; IPR000768; ART.
DR   Pfam; PF01129; ART; 1.
DR   PRINTS; PR00970; RIBTRNSFRASE.
DR   PROSITE; PS01291; ART; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU361228};
KW   NAD {ECO:0000256|RuleBase:RU361228};
KW   NADP {ECO:0000256|RuleBase:RU361228};
KW   Proteomics identification {ECO:0000213|MaxQB:E7ER42,
KW   ECO:0000213|PeptideAtlas:E7ER42};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU361228};
KW   Transferase {ECO:0000256|RuleBase:RU361228}.
FT   SIGNAL        1     26       {ECO:0000256|RuleBase:RU361228}.
FT   CHAIN        27    174       NAD(P)(+)--arginine ADP-
FT                                ribosyltransferase.
FT                                {ECO:0000256|RuleBase:RU361228}.
FT                                /FTId=PRO_5008192329.
FT   NON_TER     174    174       {ECO:0000313|Ensembl:ENSP00000425327}.
SQ   SEQUENCE   174 AA;  20134 MW;  53024752F56F9308 CRC64;
     MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK
     ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK
     MAGQSREDYI YGFQFKAFHF YLTRALQLLR KPCEASSKTV VYRTSQGTSF TFGG
//