ID   E7ER04_HUMAN            Unreviewed;       422 AA.
AC   E7ER04;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 2.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=T-cell differentiation antigen CD6 {ECO:0000313|Ensembl:ENSP00000410638};
DE   Flags: Fragment;
GN   Name=CD6 {ECO:0000313|Ensembl:ENSP00000410638};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000410638, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000410638, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000410638}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   EMBL; AP003721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ER04; -.
DR   jPOST; E7ER04; -.
DR   PeptideAtlas; E7ER04; -.
DR   PRIDE; E7ER04; -.
DR   Ensembl; ENST00000433107; ENSP00000410638; ENSG00000013725.
DR   UCSC; uc058bxe.1; human.
DR   EuPathDB; HostDB:ENSG00000013725.14; -.
DR   HGNC; HGNC:1691; CD6.
DR   OpenTargets; ENSG00000013725; -.
DR   eggNOG; ENOG410IK9E; Eukaryota.
DR   eggNOG; ENOG410YC2B; LUCA.
DR   GeneTree; ENSGT00940000161029; -.
DR   ChiTaRS; CD6; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000013725; Expressed in 185 organ(s), highest expression level in lymph node.
DR   ExpressionAtlas; E7ER04; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 2.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF00530; SRCR; 2.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 2.
DR   SUPFAM; SSF56487; SSF56487; 2.
DR   PROSITE; PS00420; SRCR_1; 1.
DR   PROSITE; PS50287; SRCR_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196,
KW   ECO:0000256|SAAS:SAAS00873970}; Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E7ER04,
KW   ECO:0000213|PeptideAtlas:E7ER04};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    422       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217321.
FT   TRANSMEM    298    323       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    156       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      161    260       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DISULFID    230    240       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   NON_TER     422    422       {ECO:0000313|Ensembl:ENSP00000410638}.
SQ   SEQUENCE   422 AA;  45002 MW;  4922D909FB5D007C CRC64;
     MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV
     RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT
     LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG
     EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC
     PGLPGQHYCG HKEDAGAVCS ASRSLHNLST PEVPASVQTV TIESSVTVKI ENKESRELML
     LIPSIVLGIL LLGSLIFIAF ILLRIKGKYV FMLPIQVQAP PPEDSDSGSD SDYEHYDFSA
     QPPVALTTFY NSQRHRVTDE EVQQSRFQMP PLEEGLEELH ASHIPTANPG HCITDPPSLG
     PQ
//