ID   E7EQN4_HUMAN            Unreviewed;       278 AA.
AC   E7EQN4;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Neurexin-1-beta {ECO:0000313|Ensembl:ENSP00000385310};
GN   Name=NRXN1 {ECO:0000313|Ensembl:ENSP00000385310};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385310, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000385310, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000385310}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AC007462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC078994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001317010.1; NM_001330081.1.
DR   UniGene; Hs.637685; -.
DR   ProteinModelPortal; E7EQN4; -.
DR   PeptideAtlas; E7EQN4; -.
DR   PRIDE; E7EQN4; -.
DR   Ensembl; ENST00000405581; ENSP00000385310; ENSG00000179915.
DR   GeneID; 9378; -.
DR   UCSC; uc061jcc.1; human.
DR   CTD; 9378; -.
DR   EuPathDB; HostDB:ENSG00000179915.21; -.
DR   HGNC; HGNC:8008; NRXN1.
DR   OpenTargets; ENSG00000179915; -.
DR   GeneTree; ENSGT00940000154292; -.
DR   OrthoDB; 35129at2759; -.
DR   ChiTaRS; NRXN1; human.
DR   GenomeRNAi; 9378; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000179915; Expressed in 176 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; E7EQN4; baseline and differential.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR001791; Laminin_G.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7EQN4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    278       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219277.
FT   DOMAIN       30    217       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      219    256       EGF-like. {ECO:0000259|PROSITE:PS50026}.
SQ   SEQUENCE   278 AA;  30371 MW;  FDDF6EC31CAB06BD CRC64;
     MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT
     RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR
     RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF
     KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ
     AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKD
//