ID   E7EQ64_HUMAN            Unreviewed;       261 AA.
AC   E7EQ64;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   SubName: Full=Trypsin-1 {ECO:0000313|Ensembl:ENSP00000417854};
GN   Name=PRSS1 {ECO:0000313|Ensembl:ENSP00000417854};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417854, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000417854, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000417854}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000487956}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC231380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC244472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E7EQ64; -.
DR   PRIDE; E7EQ64; -.
DR   Ensembl; ENST00000486171; ENSP00000417854; ENSG00000204983.
DR   Ensembl; ENST00000633245; ENSP00000487956; ENSG00000274247.
DR   UCSC; uc064itb.1; human.
DR   EuPathDB; HostDB:ENSG00000204983.12; -.
DR   HGNC; HGNC:9475; PRSS1.
DR   OpenTargets; ENSG00000204983; -.
DR   GeneTree; ENSGT00940000153485; -.
DR   OMA; HSAPHIV; -.
DR   ChiTaRS; PRSS1; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000204983; Expressed in 87 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; E7EQ64; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|EPD:E7EQ64,
KW   ECO:0000213|MaxQB:E7EQ64, ECO:0000213|PeptideAtlas:E7EQ64};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    261       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014570914.
FT   DOMAIN       24    258       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
SQ   SEQUENCE   261 AA;  28123 MW;  60F9703C60896C03 CRC64;
     MNPLLILTFV AAALAAPFDD DDKIVGGYNC EENSVPYQVS LNSGYHFCGG SLINEQWVVS
     AGHCYKSAIK SKFSGRGCEY HRIQVRLGEH NIEVLEGNEQ FINAAKIIRH PQYDRKTLNN
     DIMLIKLSSR AVINARVSTI SLPTAPPATG TKCLISGWGN TASSGADYPD ELQCLDAPVL
     SQAKCEASYP GKITSNMFCV GFLEGGKDSC QGDSGGPVVC NGQLQGVVSW GDGCAQKNKP
     GVYTKVYNYV KWIKNTIAAN S
//