ID   E7EQ29_HUMAN            Unreviewed;       546 AA.
AC   E7EQ29;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   SubName: Full=Beta-galactosidase {ECO:0000313|Ensembl:ENSP00000305920};
GN   Name=GLB1 {ECO:0000313|Ensembl:ENSP00000305920};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000305920, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000305920, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000305920}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; AC112211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EQ29; -.
DR   SMR; E7EQ29; -.
DR   jPOST; E7EQ29; -.
DR   MaxQB; E7EQ29; -.
DR   PeptideAtlas; E7EQ29; -.
DR   PRIDE; E7EQ29; -.
DR   Ensembl; ENST00000307377; ENSP00000305920; ENSG00000170266.
DR   UCSC; uc003cfj.2; human.
DR   EuPathDB; HostDB:ENSG00000170266.15; -.
DR   HGNC; HGNC:4298; GLB1.
DR   OpenTargets; ENSG00000170266; -.
DR   eggNOG; KOG0496; Eukaryota.
DR   eggNOG; COG1874; LUCA.
DR   GeneTree; ENSGT00390000006586; -.
DR   ChiTaRS; GLB1; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000170266; Expressed in 210 organ(s), highest expression level in adrenal tissue.
DR   ExpressionAtlas; E7EQ29; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 2.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 2.
DR   PIRSF; PIRSF006336; B-gal; 2.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosidase {ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00108888};
KW   Proteomics identification {ECO:0000213|EPD:E7EQ29,
KW   ECO:0000213|MaxQB:E7EQ29, ECO:0000213|PeptideAtlas:E7EQ29};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    546       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219450.
FT   DOMAIN       40     82       Glyco_hydro_35.
FT                                {ECO:0000259|Pfam:PF01301}.
FT   DOMAIN      114    225       Glyco_hydro_35.
FT                                {ECO:0000259|Pfam:PF01301}.
FT   DOMAIN      417    488       BetaGal_dom4_5.
FT                                {ECO:0000259|Pfam:PF13364}.
SQ   SEQUENCE   546 AA;  60483 MW;  2F72A0BE492536CD CRC64;
     MPGFLVRILP LLLVLLLLGP TRGLRNATQR MFEIDYSRDS FLKDGQPFRY ISGSIHYSRV
     PRFYWKDRLL KMKMAGLNAI QTLPGSCGQV VGSPSAQDEA SPLSEWRASY NSAGSNITDA
     FLSQRKCEPK GPLINSEFYT GWLDHWGQPH STIKTEAVAS SLYDILARGA SVNLYMFIGG
     TNFAYWNGAN SPYAAQPTSY DYDAPLSEAG DLTEKYFALR NIIQKFEKVP EGPIPPSTPK
     FAYGKVTLEK LKTVGAALDI LCPSGPIKSL YPLTFIQVKQ HYGFVLYRTT LPQDCSNPAP
     LSSPLNGVHD RAYVAVDGIP QGVLERNNVI TLNITGKAGA TLDLLVENMG RVNYGAYIND
     FKGLVSNLTL SSNILTDWTI FPLDTEDAVC SHLGGWGHRD SGHHDEAWAH NSSNYTLPAF
     YMGNFSIPSG IPDLPQDTFI QFPGWTKGQV WINGFNLGRY WPARGPQLTL FVPQHILMTS
     APNTITVLEL EWAPCSSDDP ELCAVTFVDR PVIGSSVTYD HPSKPVEKRL MPPPPQKNKD
     SWLDHV
//